Chemistry Heterocyclic Building Blocks Quinazolines

Quinazolines

Quinazoline is a bicyclic aromatic heterocycle comprised of two fused six-membered rings, a benzene ring and a pyrimidine ring, and has the molecular formula C8H6N2.

Quinazoline is a heterobicyclic organic compound that can be considered as the parent compound of molecules containing a fused two-ring system. It is derived from naphthalene by replacing the carbon atoms at positions 1 and 3 with nitrogen atoms.

Quinazoline, which is a benzo-fused pyrimidine, can also be referred to as benzo[d]pyrimidine according to the fusion nomenclature or as 1,3-diazanaphthalene using the replacement nomenclature.

Quinazoline, which consists of two fused six-membered aromatic rings, exhibits hypotensive and anticancer properties. Quinazoline-derived drugs such as prazosin, doxazosin, and terazosin act as α1-adrenergic receptor blockers.

While the parent quinazoline molecule is not frequently referred to in technical literature, its substituted derivatives have been created for medicinal uses like as antimalarial and anticancer agents.

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By Key Group+−

amino-quinazoline bromoquinazoline chloroquinazoline dichloroquinazoline dihydroquinazoline dimethoxyquinazoline dimethylquinazoline fluoroquinazoline hydroxyquinazolin iodoquinazoline methoxyquinazoline methylquinazoline nitroquinazoline phenylquinazolin quinazolin-one quinazoline-carboxylate quinazoline-carboxylic-acid tetrahydroquinazoline trichloroquinazoline trifluoromethyl-quinazoline

By Parent Nucleus+−

Aromatic Heterocycles Furans Morpholines Piperazines Piperidines Spiroes Tetrahydrofurans Thiadiazoles

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Alcohols Aldehydes Alkenyls Alkynyls Amides Amines Aryls Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Iodides Ketones Nitriles Nitroes Organoboron Phenols Sulfides Trifluoromethyls

Framework+−

2,4-dichloroquinazoline 2-(trifluoromethyl)quinazoline 2-bromoquinazoline 2-chloroquinazolin-4(3H)-one 2-cyclopropylquinazoline 2-mercaptoquinazolin-4(3H)-one 2-methylquinazoline 4-chloroquinazoline 4-methylquinazoline 5,6,7,8-tetrahydroquinazoline 5-chloroquinazoline 6-bromoquinazoline 7-bromoquinazolin-4(3H)-one 7-fluoroquinazolin-4(3H)-one 7-methoxy-N-phenylquinazolin-4-amine 8-bromoquinazoline 8-chloroquinazoline 8-fluoroquinazoline 8-methoxyquinazoline 8-methylquinazoline ethyl quinazoline-2-carboxylate N-(3-chlorophenyl)quinazolin-4-amine quinazolin-2-amine quinazolin-2-ol quinazolin-4-amine quinazolin-4-ol

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    By Configuration+−

    N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine

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    A100205153436-54-599+%

    N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine

    $46.00/250mg

    Detail
    2-Mercapto-3-(3-morpholinopropyl)quinazolin-4(3H)-one

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    A1010293146381-57-998%

    2-Mercapto-3-(3-morpholinopropyl)quinazolin-4(3H)-one

    $767.00/5g

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    N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine

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    A114247231278-20-998%

    N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine

    $6.00/1g

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    5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde

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    A118703231278-84-597%

    5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde

    $13.00/5g

    Detail
    3-Methyl-2-((4-methylbenzyl)thio)quinazolin-4(3H)-one

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    A122944522312-45-498%

    3-Methyl-2-((4-methylbenzyl)thio)quinazolin-4(3H)-one

    $801.00/100mg

    Detail
    2,3-Dihydroimidazo[1,2-c]quinazolin-5-amine

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    A124534427631-28-398%

    2,3-Dihydroimidazo[1,2-c]quinazolin-5-amine

    $976.00/1g

    Detail
    7-Fluoro-6-nitroquinazolin-4(3H)-one

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    A134329162012-69-398%

    7-Fluoro-6-nitroquinazolin-4(3H)-one

    $25.00/25g

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    6-Aminoquinazolin-4(3H)-one

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    A14579417329-31-695%

    6-Aminoquinazolin-4(3H)-one

    $40.00/1g

    Detail
    7-Bromo-2,4-dichloro-8-fluoro-6-iodoquinazoline

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    A14739162241720-34-197%

    7-Bromo-2,4-dichloro-8-fluoro-6-iodoquinazoline

    $26.00/100mg

    Detail
    6-Iodoquinazolin-4-one

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    A14937316064-08-797%

    6-Iodoquinazolin-4-one

    $15.00/10g

    Detail
    7-Bromo-4,6-dichloro-8-fluoroquinazoline

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    A15193891698027-19-890%

    7-Bromo-4,6-dichloro-8-fluoroquinazoline

    $113.00/100mg

    Detail
    2-(4-Oxoquinazolin-3(4H)-yl)acetic acid

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    A16145614663-53-798%

    2-(4-Oxoquinazolin-3(4H)-yl)acetic acid

    $520.00/5g

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    1,3-Dimethyl-6-nitro-3,4-dihydroquinazolin-2(1H)-one

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    A1666144233775-52-598%

    1,3-Dimethyl-6-nitro-3,4-dihydroquinazolin-2(1H)-one

    $126.00/250mg

    Detail
    4-Chloro-6,7-dimethoxyquinazoline

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    A17606213790-39-198%

    4-Chloro-6,7-dimethoxyquinazoline

    $31.00/10g

    Detail
    4-Chloro-6-iodoquinazoline

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    A23071698556-31-195%

    4-Chloro-6-iodoquinazoline

    $11.00/10g

    Detail
    N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

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    A257382162012-67-198%

    N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

    $32.00/25g

    Detail
    6-Nitroquinazolin-4(3H)-one

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    A2649526943-17-595%

    6-Nitroquinazolin-4(3H)-one

    $19.00/1g

    Detail
    6,7-Dimethoxy-1H-quinazolin-4-one

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    A26750113794-72-497%

    6,7-Dimethoxy-1H-quinazolin-4-one

    $5.00/1g

    Detail
    4-Chloro-7-fluoro-6-nitroquinazoline

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    A575241162012-70-698%

    4-Chloro-7-fluoro-6-nitroquinazoline

    $155.00/1g

    Detail
    5-Bromo-2-mercaptoquinazolin-4(3H)-one

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    A6950502231674-69-295%

    5-Bromo-2-mercaptoquinazolin-4(3H)-one

    $1203.00/1g

    Detail
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