The SLC (Solute Carrier) family is a group of transmembrane transport proteins, including multiple subfamilies and members, such as SLC1 to SLC52. They consist of multiple transmembrane domains and are mainly located on the cell membrane, responsible for transporting various solutes into and out of cells, including ions, sugars, amino acids, and drugs. The SLC family is involved in regulating the absorption of nutrients, metabolic balance, and ion homeostasis in cells, by influencing the transmembrane transport of solutes, regulating the physiological functions of cells. In different tissues and cells, the expression of SLC family members is specific, and their gene mutations or expression abnormalities are associated with various diseases, including metabolic disorders, cardiovascular diseases, and drug resistance.