Chemistry Organic Building Blocks Sulfones

Sulfones

In the field of organic chemistry, a sulfone is an organosulfur compound that features a sulfonyl (R−S(=O)2−R’) functional group attached to two carbon atoms.

All clinically significant sulfones are derivatives of dapsone, which is the most commonly used compound within this class.

Sulfones are commonly synthesized using conditions similar to those employed in Friedel-Crafts reactions, utilizing sources of RSO2+ derived from sulfonyl halides or sulfonic acid anhydrides. Lewis acid catalysts such as AlCl3 and FeCl3 are typically employed in the reaction.

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(4-(methylsulfonyl)phenyl)boronic acid (ethylsulfonyl)benzene 1-(methylsulfonyl)-3-nitrobenzene 1-(methylsulfonyl)piperazine 1-(methylsulfonyl)piperidine 1-(phenylsulfonyl)-1H-1,2,4-triazole 1-(phenylsulfonyl)-1H-imidazole 1-(phenylsulfonyl)azetidine 1-bromo-2-(methylsulfonyl)benzene 1-bromo-4-(phenylsulfonyl)benzene 1-fluoro-2-(methylsulfonyl)benzene 1-fluoro-3-(methylsulfonyl)benzene 1-methyl-3-(methylsulfonyl)benzene 2-(methylsulfonyl)aniline 2-(methylsulfonyl)pyridine 2-(methylsulfonyl)pyrimidine 3-(methylsulfonyl)aniline 3-(methylsulfonyl)benzoic acid 3-(methylsulfonyl)pyridine benzenesulfonyl fluoride tetrahydro-2H-thiopyran 1,1-dioxide tetrahydrothiophene 1,1-dioxide

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    2-Fluoro-5-(methylsulfonyl)toluene

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    a-Tosyl-(4-fluorobenzyl) isocyanide

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    4-Chloro-benzenesulfonyl fluoride

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    2-Methoxy-4-(methylsulfonyl)aniline

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    N-[(1S)-2-Hydroxy-1-methylethyl]-2-nitrobenzenesulfonamide

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    6-Aminobenzo[b]thiophene 1,1-dioxide

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    Rilematovir

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    1-Bromo-3-(isopropylsulfonyl)benzene

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    (Allylsulfonyl)benzene

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    4-(Methylsulfonyl)benzonitrile

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    1-Bromo-3-(butylsulfonyl)benzene

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    Methyl 2-amino-5-(methylsulfonyl)benzoate

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    2,3-Dihydrothiophene 1,1-dioxide

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    Methyl 2-(methylsulfonyl)acetate

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    3-[4-(Methylsulfonyl)phenyl]-5-(1-boc-4-piperidyl)-1,2,4-oxadiazole

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    3-[4-(Methylsulfonyl)phenyl]-5-(1-boc-4-piperidyl)-1,2,4-oxadiazole

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    Allyl (2-nitrophenyl)sulfonylcarbamate

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    2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

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    2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

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    2-(Methylsulfonyl)imidazole

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    2-(Methylsulfonyl)imidazole

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