Chemistry Organic Building Blocks Sulfonyl Chlorides

Sulfonyl Chlorides

The ease with which sulfonyl chlorides can react with heterocyclic amines to form intricate sulfonamide compounds makes them a favored choice of building blocks in medicinal chemistry.

The sulfonyl chlorides and fluorides are the most important, with the stability of sulfonyl halides decreasing in the following order: fluorides > chlorides > bromides > iodides.

Sulfonyl chlorides, also known as sulfonic acid chlorides, have a general formula of RSO2Cl and belong to the class of sulfonyl halides.

Benzenesulfonyl chloride is a derivative that holds significance in industry, while in the laboratory, reagents such as tosyl chloride, brosyl chloride, nosyl chloride, and mesyl chloride prove to be useful.

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By Key Group+−

benzenesulfonyl-chloride fluoro-benzenesulfonyl-chloride fluorobenzenesulfonyl trifluoromethyl-benzene-sulfonyl chloride

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Benzofurans Benzothiazoles Imidazoles Isoquinolines Isoxazoles Other Aromatic Heterocycles Piperazines Piperidines Pyrazoles Pyridines Quinolines Thiazoles

By Functional Group+−

Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Amides Amines Aryls Bromides Carboxylic Acids Chiral Building Blocks Esters Ethers Fluorinated Building Blocks Ketones Nitriles Nitroes Sulfamides Sulfones Thiophenes Trifluoromethyls

Framework+−

1H-pyrazole-4-sulfonyl chloride 2-bromobenzenesulfonyl chloride 2-chlorobenzenesulfonyl chloride 2-fluorobenzenesulfonyl chloride 2-methoxybenzenesulfonyl chloride 2-methylbenzenesulfonyl chloride 3-(chlorosulfonyl)benzoic acid 3-(trifluoromethyl)benzenesulfonyl chloride 3-chlorobenzenesulfonyl chloride 3-fluorobenzenesulfonyl chloride 4-chlorobenzenesulfonyl chloride 4-fluorobenzenesulfonyl chloride isoquinoline-5-sulfonyl chloride methyl 2-(chlorosulfonyl)benzoate phenylmethanesulfonyl chloride

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

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    1-Methyl-1H-pyrazole-4-sulfonyl chloride

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    A103074288148-34-598%

    1-Methyl-1H-pyrazole-4-sulfonyl chloride

    $6.00/250mg

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    2-Chloro-5-pyridinesulfonyl chloride

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    A1043716684-39-597%

    2-Chloro-5-pyridinesulfonyl chloride

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    6-Chloro-5-fluoropyridine-3-sulfonyl chloride

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    A10624001261737-06-795%

    6-Chloro-5-fluoropyridine-3-sulfonyl chloride

    $212.00/250mg

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    1,5-Dimethyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride

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    A107438388398-42-998%

    1,5-Dimethyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride

    $64.00/250mg

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    6-Bromopyridine-2-sulfonyl chloride

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    A132245912934-77-195%

    6-Bromopyridine-2-sulfonyl chloride

    $165.00/1g

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    6-Chloro-4-methylpyridine-3-sulfonyl chloride

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    A149023889944-76-797%

    6-Chloro-4-methylpyridine-3-sulfonyl chloride

    $21.00/100mg

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    2-Chloro-5-methylpyridine-3-sulfonyl chloride

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    A1560261208081-98-497%

    2-Chloro-5-methylpyridine-3-sulfonyl chloride

    $48.00/1g

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    2-Chloro-4-methylpyridine-3-sulfonyl chloride

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    A2182721208081-91-797%

    2-Chloro-4-methylpyridine-3-sulfonyl chloride

    $190.00/1g

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    6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

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    A224446928324-59-898%

    6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

    $563.00/1g

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    Pyridine-2-sulfonyl chloride hydrochloride

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    A241268111480-84-395%

    Pyridine-2-sulfonyl chloride hydrochloride

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    1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride

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    A26761059340-27-197%

    1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride

    $36.00/1g

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    5,6-Dichloropyridine-3-sulfonyl chloride

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    A33084698121-40-598%

    5,6-Dichloropyridine-3-sulfonyl chloride

    $354.00/1g

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    2-Chloro-6-methoxypyridine-3-sulfonyl chloride

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    A3861381208081-26-897%

    2-Chloro-6-methoxypyridine-3-sulfonyl chloride

    $279.00/1g

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    1,3-Dimethyl-1H-pyrazole-4-sulfonyl chloride

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    A47326289501-93-998%

    1,3-Dimethyl-1H-pyrazole-4-sulfonyl chloride

    $49.00/1g

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    6-Bromopyridine-3-sulfonyl chloride

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    A491336886371-20-695%

    6-Bromopyridine-3-sulfonyl chloride

    $3840.00/5g

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    5-Bromopyridine-3-sulfonyl chloride

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    A50917965001-21-098%

    5-Bromopyridine-3-sulfonyl chloride

    $25.00/250mg

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    5-Bromo-6-chloropyridine-3-sulfonyl chloride

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    A576903216394-05-795%

    5-Bromo-6-chloropyridine-3-sulfonyl chloride

    $94.00/1g

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    2,6-Dichloropyridine-3-sulfonyl chloride

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    A657457239810-43-698%

    2,6-Dichloropyridine-3-sulfonyl chloride

    $243.00/1g

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    1-Ethyl-1H-pyrazole-4-sulfonyl chloride

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    A837500957514-21-598%

    1-Ethyl-1H-pyrazole-4-sulfonyl chloride

    $18.00/250mg

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    2,5-Dichloropyridine-3-sulfonyl chloride

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    A8497471208081-36-097%

    2,5-Dichloropyridine-3-sulfonyl chloride

    $316.00/1g

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