Chemistry Heterocyclic Building Blocks Thiazolidines
Thiazolidine is a saturated, heterocyclic organic compound represented by the chemical formula (CH2)2(NH)S. This compound consists of a 5-membered ring that contains a thioether group and an amine group in positions 1 and 3, respectively. Thiazolidine is the sulfur-based equivalent of oxazolidine and is found in the form of a colorless liquid.
Thiazolidine and thiazoline are significant heterocyclic frameworks that occur in multiple natural products and synthetic compounds with biological significance, such as anticonvulsants, antidepressants, sedatives, antihypertensives, anti-inflammatories, antihistamines, and antiarthritics.
A heterocyclic compound called thiazolidine consists of a saturated ring containing five members. The ring contains a thioether group and an amine group at the 1 and 3 positions, respectively.
Prodrug derivatives of thiazolidines have been utilized to enhance the topical anti-inflammatory activity of a variety of steroids that possess a 3-carbonyl group.
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2-(3-Ethyl-4-oxothiazolidin-2-ylidene)malononitrile
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3-(Benzo[d]thiazol-2-yl)-2-(2-chloro-6-fluorophenyl)thiazolidin-4-one
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3-(3-(2-Methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4-phenylbutyl)benzamide
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5-(Furan-2-ylmethylene)-2-thioxothiazolidin-4-one