VDA (Vasorin Domain A) is an extracellular matrix protein and is one of the members of a multi-gene family. It has a complex structural composition, including multiple functional domains. In cells and tissues, VDA is primarily located near the cell membrane and in the extracellular matrix, participating in the regulation of various biological responses such as cell adhesion, migration, and signal transduction. By influencing different signaling pathways such as TGF-β, Wnt/β-catenin, it regulates cell proliferation, differentiation, and apoptosis. The specific expression of the VDA gene varies in different tissues, and its expression levels may change in conditions such as tumors and fibrosis. VDA gene mutations are relatively rare, but certain mutations may affect its function, thereby contributing to the development of diseases.