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Chemical Structure| 197850-75-2 Chemical Structure| 197850-75-2

Structure of 197850-75-2

Chemical Structure| 197850-75-2

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Product Details of [ 197850-75-2 ]

CAS No. :197850-75-2
Formula : C35H31NO11
M.W : 641.62
SMILES Code : O=C1OC2(C3=C(OC4=C2C=CC(OC(C(C)(C)C)=O)=C4)C=C(OC(C(C)(C)C)=O)C=C3)C5=C1C=CC(C(ON6C(CCC6=O)=O)=O)=C5
English Name :6-(((2,5-Dioxopyrrolidin-1-yl)oxy)carbonyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate)
MDL No. :MFCD01630924

Safety of [ 197850-75-2 ]

Application In Synthesis of [ 197850-75-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 197850-75-2 ]

[ 197850-75-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6066-82-6 ]
  • [ 192374-17-7 ]
  • [ 197850-75-2 ]
YieldReaction ConditionsOperation in experiment
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In various solvent(s)
With dicyclohexyl-carbodiimide In 1,4-dioxane for 0.416667h; Inert atmosphere;
0.64 g With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
With dicyclohexyl-carbodiimide In ethyl acetate at 20℃; 1.S3; 2-8 S3, in 250mL round bottom flask, add 5.0 grams of 6-carboxyfluorescein pivalate (9.2mmol), 1.2 grams of N-hydroxysuccinimide (10.4mmol) and 2.0 gramsN,N'-dicyclohexylcarbodiimide (9.7mmol), then add 60 ml of ethyl acetate, stir and react at room temperature for one hour, after TLC monitors that the reaction is complete, filter and remove the solid generated in the bottle, and wash the filtrate with water The organic phase was then evaporated to dryness to obtain the product4.8 g of 6-carboxyfluorescein-N-succinimide was used for the next reaction without further purification. The product obtained in the previous step (4.8 g, 7.5 mmol) was dissolved in 60 ml of dichloromethane, then 1.3 g of 6-amino-1-hexanol (11.2 mmol) was added, and the reaction was stirred at room temperature for one hour, and the reaction was monitored by TLC. Finally, 60 ml of water was added, and the lower organic phase was removed to evaporate the solvent to obtain 3.6 g of a yellow solid, which was put into the next reaction without further purification.

 

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