Home Chemistry Heterocyclic Building Blocks Pyrrolidines 3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One
Nucleophilic Addition Reactions: The ketone carbonyl group can undergo nucleophilic addition reactions with various nucleophiles such as Grignard reagents, organolithium compounds, amines, and hydride donors (e.g., sodium borohydride or lithium aluminum hydride) to form secondary or tertiary alcohols.
Acylation Reactions: The ketone carbonyl group can react with acylating agents (e.g., acyl chlorides or anhydrides) in the presence of a Lewis acid (such as aluminum chloride) to form ketones with different substituents.
Reductive Amination: The compound can undergo reductive amination reactions by reacting with primary or secondary amines in the presence of a reducing agent (e.g., sodium cyanoborohydride) to form secondary or tertiary amines.
Ring Closure: Depending on the reaction conditions and reagents, it may be possible to form cyclic compounds through intramolecular reactions. For example, cyclization reactions could occur to form a cyclic amine or lactam.
Oxidation Reactions: The ketone functionality can be oxidized to form a carboxylic acid or other oxidation products using strong oxidizing agents like potassium permanganate or chromic acid.
Reduction of the Carbonyl Group: The ketone functionality can be reduced to an alcohol using various reducing agents like sodium borohydride or lithium aluminum hydride.
Substitution Reactions: Depending on the reaction conditions, the phenyl group may undergo substitution reactions, such as electrophilic aromatic substitution reactions with appropriate reagents.
Enamine Formation: The compound may form an enamine with a primary amine under certain conditions, which can further react in various ways.
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(S)-2-Amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one
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H-Gly-Tyr-Pro-Gly-Gln-Val-OH trifluoroacetate
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