Home Chemistry Organic Building Blocks Chlorides 3-Chloro-4-Fluoroaniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—F,—NH2).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Reimer-Tiemann Reaction: Aniline can react with chloroform (CHCl3) and a base to undergo the Reimer-Tiemann reaction, leading to the formation of a salicylaldehyde derivative.
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3-Chloro-4-fluoro-5-(trifluoromethyl)aniline
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