Home Chemistry Organic Building Blocks Phenols 2-(Difluoromethoxy)Phenol
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —OCHF2,—OH).
Electrophilic Aromatic Substitution (EAS): The benzene ring could undergo electrophilic aromatic substitution reactions, such as nitration, sulfonation, halogenation, or Friedel-Crafts acylation/alkylation, depending on the reagents and conditions used.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.
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4-(Difluoromethoxy)-3-hydroxybenzaldehyde
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3-(Difluoromethoxy)-4-hydroxybenzaldehyde
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Methyl 4-(difluoromethoxy)-3-hydroxybenzoate
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4-(Difluoromethoxy)-3-hydroxybenzoic acid
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