Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-6-Methyl-3-Nitropyridine
Substitution Reactions: The chlorine atom and the nitro group can undergo substitution reactions with nucleophiles or electrophiles. For instance, nucleophilic substitution at the chlorine atom can result in the replacement of chlorine with another nucleophile.
Reduction: The nitro group (-NO2) can be reduced to the corresponding amine (-NH2) under suitable conditions. This reduction can be achieved using various reducing agents like hydrogen gas with a metal catalyst, iron and hydrochloric acid, or using other reagents such as tin(II) chloride and hydrochloric acid.
Nitration: The aromatic ring can undergo nitration reactions under certain conditions, leading to the introduction of a nitro group at positions ortho, meta, or para to the existing nitro group.
Alkylation or Acylation: The aromatic ring can undergo Friedel-Crafts alkylation or acylation reactions, where an alkyl or acyl group is introduced onto the aromatic ring.
Reductive Amination: The compound can undergo reductive amination, where the nitro group is reduced to an amine group, followed by the reaction of the amine with a suitable carbonyl compound to form an imine, which is then reduced to the amine.
Heterocyclic Synthesis: The compound can participate in various heterocyclic synthesis reactions due to the presence of the pyridine ring and functional groups. These reactions may involve cyclization processes to form fused or spiro heterocycles.
Oxidation: The methyl group can be oxidized to a carboxylic acid group under certain conditions, such as using strong oxidizing agents like potassium permanganate or chromic acid.
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2-Chloro-4-methoxy-6-methyl-3-nitropyridine
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