Chemistry Heterocyclic Building Blocks Tetrazoles
Tetrazoles are a type of synthetic organic heterocyclic compound that comprises a 5-member ring containing four nitrogen atoms and one carbon atom.
Because tetrazoles are deprotonated at physiological pH and have a similar pKa value, they can serve as bioisosteres for carboxylate groups.
Losartan and candesartan are types of Angiotensin II receptor blockers, which are commonly classified as tetrazoles. An example of a well-known tetrazole is MTT (dimethyl thiazolyl diphenyl tetrazolium bromide).
The tetrazole ring is a common feature among pharmaceutical drugs with antihypertensive effects, as well as those with antibiotic and anti-allergic properties.
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(2-(1H-Tetrazol-5-yl)phenyl)boronic acid
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N-(3-(5-Mercapto-1H-tetrazol-1-yl)phenyl)acetamide
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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(1H-tetrazol-5-yl)butanoic acid
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1,3-Benzenedicarboxylic acid, 5-(2H-tetrazol-5-yl)-
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5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
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1-(2-Dimethylaminoethyl)-5-mercapto-1,2,3,4-tetrazole
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(1H-Tetrazol-5-yl)methanamine hydrochloride
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5-(4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
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4-(5-Mercapto-1H-tetrazol-1-yl)benzoic acid