Home Chemistry Heterocyclic Building Blocks Pyrans 1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
Substitution Reactions: The indazole ring can undergo various substitution reactions, such as electrophilic aromatic substitution. For example, you can introduce substituents (e.g., alkyl, aryl, or halogen groups) at the indazole ring's positions by reacting it with appropriate reagents.
Oxidation: The tetrahydro-2H-pyran ring can be oxidized to form the corresponding lactone or other oxygen-containing functional groups. This can be achieved using oxidizing agents like peroxides or chromates.
Reduction: The compound can undergo reduction reactions, especially at the tetrahydro-2H-pyran ring. Common reducing agents like hydrogen and a metal catalyst can be used to reduce the double bond in the tetrahydro-2H-pyran ring.
Ring-Opening Reactions: Depending on the conditions, the tetrahydro-2H-pyran ring can undergo ring-opening reactions, leading to the formation of open-chain compounds.
Cyclization Reactions: In the presence of suitable reagents and conditions, the compound can participate in cyclization reactions, forming new rings or rearranged products.
Arylation and Alkylation: The indazole ring can be arylated or alkylated at various positions using appropriate reagents and catalysts.
Heterocyclic Chemistry: Depending on the reaction conditions and reagents, the compound may engage in heterocyclic chemistry, leading to the formation of new heterocyclic rings or rearranged structures.
Metal-Catalyzed Reactions: Transition metal catalysts can facilitate various reactions, including cross-coupling reactions, which can be useful for synthesizing more complex molecules.
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1-(Tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1H-indazol-4-ol
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[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid
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6-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
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(1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)boronic acid
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(1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)boronic acid
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(1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)boronic acid
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1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole-6-carboxylic acid
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1-(Tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carboxylic acid
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5-Nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
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1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine
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1-(Tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine
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4-Bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
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5-Bromo-6-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
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(1-(Tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1H-indazol-4-yl)boronic acid
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