Home Chemistry Heterocyclic Building Blocks Thiazoles 2-Phenoxythiazole
Ring Opening:Acid-Catalyzed Ring Opening: 1,3-Dioxane can undergo acid-catalyzed ring opening, especially with strong acids like sulfuric acid. The oxygen atoms in the ring can be protonated, leading to cleavage of the ring and formation of open-chain diols.
Ether Cleavage:Reaction with Strong Reducing Agents: 1,3-Dioxane can undergo cleavage when treated with strong reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4). These reagents can break the oxygen-oxygen bond in the dioxane ring, producing alcohol derivatives.
Nucleophilic Substitution:Nucleophilic substitution reactions can occur at the carbon atoms adjacent to the oxygen atoms. For example, nucleophiles like alkoxides or amines can replace one of the oxygen atoms.
Esterification:1,3-Dioxane can undergo esterification reactions with carboxylic acids and acid catalysts to form dioxane esters.
Reaction with Alkyl Halides:In the presence of appropriate catalysts or nucleophiles, 1,3-dioxane can react with alkyl halides via nucleophilic substitution reactions, leading to the formation of alkylated dioxane derivatives.
Oxidation:1,3-Dioxane can be oxidized using strong oxidizing agents like potassium permanganate (KMnO4) or chromic acid to produce various functional groups, such as ketones or carboxylic acids.
Polymerization:Under certain conditions, 1,3-dioxane can undergo polymerization reactions to form long-chain polymers.
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2-(4-(Trifluoromethyl)phenoxy)thiazole-5-carboxylic acid
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2-(4-Fluorophenoxy)thiazole-5-carboxylic acid
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2-(4-Chlorophenoxy)thiazole-5-carboxylic acid
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