Home Chemistry Heterocyclic Building Blocks Indoles 2-(1H-Indol-3-Yl)Ethan-1-Amine
Friedel-Crafts Acylation or Alkylation: The indole ring may react with acyl or alkyl groups in the presence of a Lewis acid catalyst.
Nucleophilic Substitution: The amine group can participate in nucleophilic substitution reactions with electrophiles, such as alkyl halides, leading to the formation of N-substituted tryptamines.
Reaction with Carbonyl Compounds: The amine group can undergo reductive amination reactions with carbonyl compounds (aldehydes or ketones) in the presence of a reducing agent, forming secondary or tertiary amines.
Reaction with Acyl Chlorides or Acid Anhydrides: The amine group can react with acyl chlorides or acid anhydrides|http://www.ambeed.com/Anhydrides.html】 to form amides.
Indole Ring Oxidation: The indole ring can be oxidized under certain conditions, leading to the formation of oxindole derivatives.
Reaction with Carbonyl Compounds: The amine group can form a Schiff base with carbonyl compounds in the presence of acidic conditions.
Cyclization: The compound may undergo cyclization reactions, forming additional heterocyclic structures under specific conditions.
Reaction with Formaldehyde and a Carbonyl Compound: Tryptamine can undergo a Mannich reaction, involving formaldehyde and a carbonyl compound, to form a β-amino ketone.
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3-(2-Aminoethyl)-1H-indole-6-carbonitrile
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3-(2-Aminoethyl)-1H-indole-6-carbonitrile hydrochloride
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3-(2-Aminoethyl)-1H-indole-5-carbonitrile hydrochloride
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