Home Chemistry Heterocyclic Building Blocks Indazoles Methyl 1H-Indazole-6-Carboxylate
Nucleophilic Substitution: The carboxylate group can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of substituted esters.
Acylation: The nitrogen atom in the indazole ring can undergo acylation reactions to form N-acyl derivatives.
Reduction: The carbonyl group of the ester can be reduced to form the corresponding alcohol using reducing agents such as lithium aluminum hydride or sodium borohydride.
Oxidation: The alcohol group can be oxidized to form the corresponding aldehyde or carboxylic acid under appropriate conditions.
Ring-opening Reactions: The indazole ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Esterification: The alcohol group can react with carboxylic acids or acid derivatives to form esters through esterification reactions.
Substitution Reactions on the Indazole Ring: The indazole ring can undergo various substitution reactions, such as nucleophilic aromatic substitution, electrophilic aromatic substitution, or metal-catalyzed reactions.
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