The serum and glucocorticoid-regulated kinase (SGK) family comprises three members: SGK1, SGK2, and SGK3. They are serine/threonine kinases structurally similar to AKT. SGK is expressed in various cells and tissues, particularly upregulated under stress and hormone stimulation. SGK regulates ion channels, transporters, as well as signaling pathways related to cell survival, differentiation, and proliferation. Specific gene expression and activity regulation of SGK are crucial for maintaining electrolyte balance and promoting cell survival. Aberrant expression or functional variations of SGK genes are closely associated with cardiovascular diseases, tumorigenesis, diabetes, and other disorders.