Home Chemistry Heterocyclic Building Blocks Pyridines 6-Chloropyridin-2-Amine
Nucleophilic substitution: The amine group can undergo nucleophilic substitution reactions with electrophiles, such as alkyl halides or acyl halides, leading to the formation of N-substituted or N-acylated derivatives.
Reductive amination: The amine group can react with carbonyl compounds (aldehydes or ketones) in the presence of reducing agents like sodium cyanoborohydride to form secondary or tertiary amines.
Acylation: The amine group can undergo acylation reactions with acyl chlorides or acid anhydrides to yield amides.
Metalation: The amino group can be deprotonated under appropriate conditions to form a metal-amide complex. This complex can participate in various reactions, including metal-catalyzed coupling reactions.
Diazotization: The amino group can undergo diazotization with nitrous acid (generated in situ from sodium nitrite and a mineral acid) to form a diazonium salt, which can further react with various nucleophiles to form azo compounds or diazo derivatives.
Hofmann rearrangement: Under certain conditions, the amine group can undergo Hofmann rearrangement to yield an isocyanate.
Oxidation: The amino group can be oxidized to form corresponding nitroso, nitro, or N-oxide derivatives under appropriate conditions.
Sulfonation: The amine group can react with sulfur trioxide or sulfuric acid to yield sulfonamide derivatives.
Halogenation: The pyridine ring can undergo halogenation reactions at positions adjacent to the chlorine atom, leading to the formation of dihalopyridine derivatives.
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6-Chloro-4-(trifluoromethyl)pyridin-2-amine
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