Chemistry Heterocyclic Building Blocks Pyrrolidines 3-Bromopyrrolidine

3-Bromopyrrolidine

These compounds have the same murcko framework: 3-bromopyrrolidine

Nucleophilic Substitution: The bromine atom can undergo nucleophilic substitution reactions with various nucleophiles to form substituted pyrrolidine derivatives.
Alkylation: The nitrogen atom can be alkylated by reaction with alkyl halides or sulfonates.
Substitution Reactions: The bromine atom can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution.
Reduction: The bromine atom can be replaced with a hydrogen atom through reduction reactions using appropriate reducing agents.
Ring-opening Reactions: The pyrrolidine ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
Cross-Coupling Reactions: The bromine atom can participate in cross-coupling reactions, such as Suzuki coupling or Heck coupling, to form biaryl or heteroaryl compounds.
Halogenation: The hydrogen atoms on the pyrrolidine ring can be replaced with halogen atoms through halogenation reactions.
Nucleophilic Addition: The double bond of the pyrrolidine ring can undergo nucleophilic addition reactions with nucleophiles.

Further Reading:

Framework+−

(3Ar,6As)-Octahydrocyclopenta[C]Pyrrole (9H-Fluoren-9-Yl)Methyl Pyrrolidine-1-Carboxylate (R)-1-((Benzyloxy)Carbonyl)Pyrrolidine-3-Carboxylic Acid (R)-2-Benzhydrylpyrrolidine (R)-3-(Pyrrolidin-2-Yl)Pyridine (R)-3-Benzylpyrrolidine (R)-3-Phenylpyrrolidine (S)-2-Benzhydrylpyrrolidine (S)-3-Phenylpyrrolidine (S)-N-(((S)-Tetrahydro-2H-Pyran-2-Yl)Methyl)Pyrrolidine-2-Carboxamide (S)-N-(4-(Thiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide (S)-N-Phenethyl-3-(Pyrrolidin-2-Yl)Propanamide 1-((Benzyloxy)Carbonyl)Pyrrolidine-3-Carboxylic Acid 1-(3-Chlorophenyl)Pyrrolidine 1-(Phenylsulfonyl)Pyrrolidine 1-(Pyrrolidin-1-Yl)Ethan-1-One 1-Benzyl 2-Methyl Pyrrolidine-1,2-Dicarboxylate 1-Benzylpyrrolidin-2-One 1-Benzylpyrrolidine 1-Methylpyrrolidin-2-One 1-Phenylpyrrolidin-2-One 2,2-Dimethylpyrrolidine 2,5-Dioxopyrrolidin-1-Yl ((Benzyloxy)Carbonyl)Glycinate 2,5-Dioxopyrrolidin-1-Yl Benzoate 2,8-Diazaspiro[4.5]Decan-3-One 2-((3-Phenylpropyl)Amino)-1-(Pyrrolidin-1-Yl)Ethan-1-One 2-(2-Chlorophenyl)Pyrrolidine 2-(2-Fluorophenyl)Pyrrolidine 2-(3-Fluorophenyl)Pyrrolidine 2-(Methoxymethyl)Pyrrolidine 2-(Pyrrolidin-1-Yl)Benzoic Acid 2-(Pyrrolidin-1-Yl)Pyridine 2-(Pyrrolidin-1-Yl)Pyrimidine 2-(Pyrrolidin-2-Yl)Acetic Acid 2-(Pyrrolidin-2-Yl)Pyridine 2-(Pyrrolidin-3-Yl)Acetic Acid 2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One 2-Azabicyclo[2.2.1]Heptane 2-Methyl-1-Phenyl-1H-Pyrrole 2-Methylpyrrolidine 3,3-Difluoropyrrolidine 3-(Pyrrolidin-2-Yl)Pyridine 3-Aminopyrrolidin-2-One 3-Bromopyrrolidine 3-Hydroxypyrrolidin-2-One 3-Phenoxypyrrolidine 3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One 3-Phenylpyrrolidine 4-(Hydroxymethyl)Pyrrolidin-2-One 4-(Pyrrolidin-1-Yl)Aniline 4-(Pyrrolidin-1-Yl)Piperidine 4-Hydroxypyrrolidin-2-One 4-Phenylpyrrolidin-2-One 4H-Thieno[3,4-C]Pyrrole-4,6(5H)-Dione 5-(Aminomethyl)Pyrrolidin-2-One 5-(Hydroxymethyl)Pyrrolidin-2-One 5-Azaspiro[2.4]Heptane 5-Oxopyrrolidine-2-Carboxylic Acid 6-Azaspiro[3.4]Octane Benzyl (R)-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate Benzyl (R)-3-Aminopyrrolidine-1-Carboxylate Benzyl (S)-Pyrrolidin-3-Ylcarbamate Benzyl 3-Hydroxypyrrolidine-1-Carboxylate Benzyl-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate Benzyl-3-Aminopyrrolidine-1-Carboxylate Ethyl 5-Oxopyrrolidine-2-Carboxylate Hexahydro-1H-Pyrrolizine Methyl 5-Oxopyrrolidine-2-Carboxylate Methyl Prolinate Methyl Pyrrolidine-3-Carboxylate N,N-Dimethylpyrrolidin-3-Amine N-Methylpyrrolidin-3-Amine Octahydrocyclopenta[C]Pyrrole Phenyl(Pyrrolidin-1-Yl)Methanone Proline Pyrrolidin-2-Ylmethanamine Pyrrolidin-2-Ylmethanol Pyrrolidin-3-Ol Pyrrolidin-3-Ylmethanamine Pyrrolidin-3-Ylmethanol Pyrrolidine-2-Carbonitrile Pyrrolidine-2-Carboxamide Pyrrolidine-3-Carbonitrile Pyrrolidine-3-Carboxylic Acid Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate Tert-Butyl 3-((Methylsulfonyl)Oxy)Pyrrolidine-1-Carboxylate Tert-Butyl 3-Hydroxypyrrolidine-1-Carboxylate Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate Tert-Butyl Pyrrolidin-3-Ylcarbamate Tert-Butyl Pyrrolidine-1-Carboxylate

By Key Group+−

Acetylpyrrolidine Aminopyrrolidine Benzylpyrrolidine Bipyrrolidine Bromopyrrolidine Carbamoylpyrrolidine Cyanopyrrolidine Difluoropyrrolidine Dihydroxy-Pyrrolidine Dihydroxypyrrolidine Dimethylpyrrolidine Dioxaborolane-Pyrrolidine Dioxopyrrolidin Ethylpyrrolidine Fluoropyrrolidine Formylpyrrolidine Hydroxypyrrolidine Mercaptopyrrolidine Methoxypyrrolidine Methylenepyrrolidine Methylpyrrolidine Other-Pyrrolidine Phenoxypyrrolidine Phenylpyrrolidine Pyridine-Pyrrolidine Pyrrolidin-Amine Pyrrolidin-Pyridine Pyrrolidine-Benzene-Boronic Acid Pyrrolidine-Benzene-Boronic Acid/Ester Pyrrolidine-Benzene-Boronic-Acid Pyrrolidine-Carboxylate Pyrrolidine-Carboxylic Acid Pyrrolidine-Hydrochloride Pyrrolidine-Hydroxy Pyrrolidine-Methanol Pyrrolidine-Nitrile Pyrrolidine-Pyrimidine Pyrrolidinone Trifluoromethyl-Phenyl-Pyrrolidine

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