Home Chemistry Heterocyclic Building Blocks Quinolines 7-(Benzyloxy)Quinoline
Nucleophilic Substitution: The benzyloxy group can be replaced by other nucleophiles, such as halogens, amines, or alkoxides. For example, you can perform a Williamson ether synthesis to replace the benzyloxy group with an alkyl or aryl group.
Arylation: You can perform palladium-catalyzed C-H arylation reactions to introduce aryl groups at various positions on the quinoline ring. This can be useful for functionalization and diversification of the molecule.
Reductive Reactions: 7-(Benzyloxy)quinoline can be subjected to various reductive reactions, such as catalytic hydrogenation or the use of reducing agents, to modify functional groups.
Oxidative Reactions: Oxidative reactions, such as the use of strong oxidizing agents, can introduce new functional groups or modify existing ones.
Alkylation: The nitrogen atom in the quinoline ring can undergo alkylation reactions, allowing the introduction of alkyl groups. This can be achieved using alkyl halides or other alkylating agents.
Halogenation: The quinoline ring can be halogenated using various halogenation agents to introduce halogen atoms (e.g., chlorine, bromine) at specific positions.
Cross-Coupling Reactions: You can perform cross-coupling reactions with various coupling partners to introduce different functional groups.
Base-Catalyzed Reactions: Reactions involving the use of strong bases can lead to deprotonation and subsequent reactions at various positions.
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7-(Benzyloxy)-4-chloro-6-methoxyquinoline
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