The ROR (Retinoic Acid Receptor-Related Orphan Receptor) family comprises RORα, RORβ, and RORγ, belonging to the nuclear receptor superfamily, with specific DNA-binding domains and ligand-binding domains. They exhibit diverse expression patterns in various cells and tissues, including immune cells, the brain, and muscles, regulating multiple biological processes such as immune responses, metabolism, and neural development. By recognizing and activating the expression of specific genes, ROR proteins participate in multiple signaling pathways, including Th17 cell differentiation and circadian rhythm regulation. The specific expression and functional mutations of ROR genes are associated with the occurrence and development of various diseases, including autoimmune diseases, metabolic disorders, and cancer.