Chemistry Heterocyclic Building Blocks Piperidines Piperidine-2,4-Dione

Piperidine-2,4-Dione

Reduction: Piperidine-2,4-dione can be reduced to piperidine-2,4-diol using reducing agents like sodium borohydride or catalytic hydrogenation. Oxidation: Piperidine-2,4-dione can be oxidized to form piperidine-2,4-dione dicarboxylic acid or related compounds by using strong oxidizing agents. Substitution reactions: The carbonyl groups in piperidine-2,4-dione can undergo nucleophilic addition reactions with various nucleophiles to yield products with different functional groups. For example, the amino group of piperidine-2,4-dione can be acylated or alkylated. Hydrolysis: Piperidine-2,4-dione can be hydrolyzed to yield piperidine-2,4-dicarboxylic acid or related compounds under basic or acidic conditions. Condensation reactions: Piperidine-2,4-dione can participate in condensation reactions with other compounds, forming new heterocyclic or aromatic compounds. Esterification: Piperidine-2,4-dione can be esterified to form esters under appropriate conditions using acid chlorides or anhydrides. Grignard reactions: It can react with Grignard reagents to form various products through nucleophilic addition.

Further Reading:

Framework+−

(9H-Fluoren-9-Yl)Methyl Piperidine-1-Carboxylate (E)-N-(3-Oxo-1-Phenyl-3-(Piperidin-1-Yl)Prop-1-En-2-Yl)Benzamide (R)-2-Phenylpiperidine (R)-3-Aminopiperidin-2-One (R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (S)-2-Phenylpiperidine (S)-N-Phenylpiperidine-2-Carboxamide 1,3-Dihydrospiro[Indene-2,4'-Piperidine] 1,4'-Bipiperidine 1-((Benzyloxy)Carbonyl)Piperidine-2-Carboxylic Acid 1-((Benzyloxy)Carbonyl)Piperidine-3-Carboxylic Acid 1-(Methylsulfonyl)Piperidine 1-(Phenylsulfonyl)Piperidine 1-(Piperidin-1-Yl)Ethan-1-One 1-(Piperidin-4-Yl)Piperazine 1-Benzyl 3-Methyl Piperidine-1,3-Dicarboxylate 1-Benzyl-N-Methylpiperidin-3-Amine 1-Benzylpiperidin-3-One 1-Benzylpiperidin-4-Amine 1-Benzylpiperidin-4-One 1-Isopropylpiperidine 1-Methyl-4-Phenylpiperidine 1-Methylpiperidin-2-One 1-Oxa-8-Azaspiro[4.5]Decane 1-Phenylpiperidin-2-One 2,2-Dimethylpiperidin-4-One 2,2-Dimethylpiperidine 2,7-Diazaspiro[3.5]Nonane 2,8-Diazaspiro[4.5]Decan-3-One 2,8-Diazaspiro[4.5]Decane 2-(Piperidin-1-Yl)Ethan-1-Amine 2-(Piperidin-1-Yl)Ethan-1-Ol 2-(Piperidin-1-Yl)Pyridine 2-(Piperidin-1-Yl)Pyrimidine 2-(Piperidin-2-Yl)Ethan-1-Ol 2-(Piperidin-4-Yl)Ethan-1-Ol 2-(Piperidin-4-Yl)Pyridine 2-Methylpiperidin-4-One 2-Methylpiperidine 2-Phenylpiperidine 3,3-Difluoropiperidin-4-One 3,3-Difluoropiperidine 3,3-Dimethylpiperidin-4-One 3,3-Dimethylpiperidine 3-(1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione 3-(Piperidin-1-Yl)Pyridine 3-(Piperidin-4-Yl)-1H-Indazole 3-(Piperidin-4-Yl)-1H-Indole 3-(Piperidin-4-Yl)Pyridine 3-Fluoropiperidin-4-One 3-Fluoropiperidine 3-Methoxypiperidine 3-Methylpiperidin-4-One 3-Methylpiperidine 3-Phenylpiperidine 4,4-Difluoropiperidine 4-(1H-Pyrazol-1-Yl)Piperidine 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine 4-(Azetidin-1-Yl)Piperidine 4-(Benzyloxy)Piperidine 4-(Piperidin-1-Yl)Pyrimidine 4-(Pyrrolidin-1-Yl)Piperidine 4-Benzylpiperidine 4-Hydrazineylpiperidine 4-Hydroxypiperidin-2-One 4-Methyl-1-Phenylpiperidine 4-Methylenepiperidine 4-Oxopiperidine-2-Carboxylic Acid 4-Phenylpiperidin-4-Ol 5-Hydroxypiperidin-2-One 6-Azaspiro[2.5]Octane 6-Oxopiperidine-2-Carboxylic Acid 7-Azaspiro[3.5]Nonane Azepane Benzyl (R)-3-Aminopiperidine-1-Carboxylate Benzyl 3-Hydroxypiperidine-1-Carboxylate Benzyl 4-Oxopiperidine-1-Carboxylate Benzyl Piperidin-4-Ylcarbamate Benzyl Piperidine-1-Carboxylate Benzyl-3-Aminopiperidine-1-Carboxylate Ethyl Piperidine-1-Carboxylate Ethyl Piperidine-2-Carboxylate Ethyl Piperidine-3-Carboxylate Ethyl Piperidine-4-Carboxylate Methyl 4-Oxopiperidine-2-Carboxylate Methyl Piperidine-2-Carboxylate Methyl Piperidine-3-Carboxylate N-Benzylpiperidin-4-Amine N-Methylpiperidin-3-Amine N-Phenylpiperidin-4-Amine N-Phenylpiperidine-2-Carboxamide Phenyl(Piperidin-1-Yl)Methanone Phenyl(Piperidin-4-Yl)Methanone Piperidin-2-Ylmethanamine Piperidin-2-Ylmethanol Piperidin-3-Amine Piperidin-3-Ol Piperidin-3-One Piperidin-3-Ylmethanamine Piperidin-3-Ylmethanol Piperidin-4-Amine Piperidin-4-Ol Piperidin-4-Ylmethanamine Piperidin-4-Ylmethanol Piperidine-2,4-Dione Piperidine-2,6-Dione Piperidine-2-Carboxylic Acid Piperidine-3-Carboxamide Piperidine-3-Carboxylic Acid Piperidine-4-Carboxylic Acid Quinuclidine Spiro[Benzo[D][1,3]Oxazine-4,4'-Piperidin]-2(1H)-One Spiro[Chromane-2,4'-Piperidin]-4-One Spiro[Indene-2,4'-Piperidin]-1(3H)-One Spiro[Indoline-3,4'-Piperidin]-2-One Spiro[Indoline-3,4'-Piperidine] Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (Piperidin-3-Ylmethyl)Carbamate Tert-Butyl 2-Oxopiperidine-1-Carboxylate Tert-Butyl 3-Bromopiperidine-1-Carboxylate Tert-Butyl 4-Oxopiperidine-1-Carboxylate Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate Tert-Butyl 4-Phenylpiperidine-1-Carboxylate Tert-Butyl Piperidin-3-Ylcarbamate

By Key Group+−

Acetylpiperidine Aminopiperidine Benzoylpiperidine Benzylpiperidine Bipiperidine Boc-Piperidine Boronate-Piperidine-Carboxylate Bromopiperidine Carbamoylpiperidine Chloropiperidine Cyanopiperidine Cyclopropylpiperidin Difluoromethyl-Piperidine Difluoropiperidine Dimethylpiperidine Dioxaborolane-Piperidine Dioxopiperidine Ethylpiperidine Ethynylpiperidine Fluoropiperidine Formylpiperidine Hydroxyethyl-Piperidine-Carboxylate Hydroxymethyl-Piperidine-Carboxylate Hydroxypiperidine Indazole-Piperidine-Carboxylate Indoline-Piperidine Isopropylpiperidine Methoxypiperidine Methylenepiperidine Methylpiperidine Oxoethyl-Piperidine-Carboxylate Oxopiperidine Pentamethylpiperidin Phenoxypiperidine Phenyl-Sulfonyl-Piperidine Phenylpiperidine Piperidin-Amine Piperidin-Imidazolyl Piperidine-Benzimidazole Piperidine-Benzofuran Piperidine-Carboxylate Piperidine-Carboxylate-Hydrochloride Piperidine-Carboxylic Acid Piperidine-Ethanol Piperidine-Hydrochloride Piperidine-Indole Piperidine-Methanamine Piperidine-Methanone Piperidine-Nitrile Piperidine-Piperidine Piperidine-Propanol Piperidine-Pyrimidine Piperidine-Triazole Piperidineacetic Piperidinecarboxylate Piperidinecarboxylic Piperidinemethanol Piperidinone Piperidinyl-Phenyl-Boronic Acid Piperidinyl-Phenyl-Boronic Acid/Ester Piperidinyl-Phenyl-Boronic-Acid Propylpiperidine Pyrazole-Piperidine Pyridin-Piperidine Spiro-Benzofuran-Piperidine Tetrahydropyrazolopyridine Tetramethylpiperidine Trifluoromethyl-Phenyl-Piperidine Trifluoromethyl-Piperidine

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Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Azoes Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydroxylamines Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Thioureas Trifluoromethyls Ureas

Heterocyclic related+−

Metal Catalysts Piperidines

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