Home Chemistry Heterocyclic Building Blocks Indazoles 5-Nitro-1H-Indazole
Reduction: The nitro group can be reduced to the corresponding amino group using reducing agents such as iron and hydrochloric acid, tin and hydrochloric acid, or other metal-based reducing agents.
Substitution Reactions: The nitro group can undergo nucleophilic substitution reactions, such as reduction to an amine, or displacement by various nucleophiles to form substituted derivatives.
Electrophilic Aromatic Substitution (EAS): The indazole ring can undergo EAS reactions with electrophiles such as acyl halides, alkyl halides, or other electrophilic reagents to introduce substituents at the 3-position or 4-position of the indazole ring.
Metalation: The indazole ring can be metalated at the 3-position or 4-position with strong bases such as butyllithium or sodium amide, followed by reactions with electrophiles to introduce various functional groups.
Reductive Amination: The nitro group can be reduced to the corresponding amines, followed by reductive amination reactions to introduce additional substituents at the amine group.
Oxidation: The nitrogen atom in the indazole ring can be oxidized to form N-oxide or other oxidized derivatives under suitable conditions.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
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