Chemistry Organic Building Blocks Ketones 1-(3-Hydroxyphenyl)Ethan-1-One

1-(3-Hydroxyphenyl)Ethan-1-One

These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —C(O)CH3,—OH).

Grignard Reaction: Acetophenone can react with Grignard reagents (alkyl or aryl magnesium halides) to form tertiary 【alcohols|https://www.ambeed.com/alcohols.html】 after acidic workup.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.

Further Reading:

Framework+−

(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (2-Aminophenyl)(Phenyl)Methanone (2-Bromophenyl)(Phenyl)Methanone (2-Chlorophenyl)(Phenyl)Methanone (2-Fluorophenyl)(Phenyl)Methanone (2-Hydroxyphenyl)(Phenyl)Methanone (2-Iodophenyl)(Phenyl)Methanone (3-Chlorophenyl)(Phenyl)Methanone (3-Fluorophenyl)(Phenyl)Methanone (3-Nitrophenyl)(Phenyl)Methanone (4-Aminophenyl)(Phenyl)Methanone (4-Bromophenyl)(Phenyl)Methanone (4-Chlorophenyl)(Phenyl)Methanone (4-Fluorophenyl)(Phenyl)Methanone (4-Hydroxyphenyl)(Phenyl)Methanone (4-Methoxyphenyl)(Phenyl)Methanone (4-Nitrophenyl)(Phenyl)Methanone (8S,14R)-6,7,8,9,10,11,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[A]Phenanthren-3-One (E)-1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (R)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-8-One 1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate 1,3-Diphenylpropan-1-One 1,4-Diazepan-5-One 1,4-Dihydroisoquinolin-3(2H)-One 1-(1H-Indazol-1-Yl)Ethan-1-One 1-(1H-Indol-1-Yl)Ethan-1-One 1-(1H-Indol-3-Yl)Ethan-1-One 1-(1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Ethan-1-One 1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One 1-(2-Aminophenyl)Ethan-1-One 1-(2-Bromophenyl)Ethan-1-One 1-(2-Chlorophenyl)Ethan-1-One 1-(2-Fluorophenyl)Ethan-1-One 1-(2-Hydroxyphenyl)-2-Phenylethan-1-One 1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One 1-(2-Hydroxyphenyl)Ethan-1-One 1-(2-Iodophenyl)Ethan-1-One 1-(2-Methoxyphenyl)Ethan-1-One 1-(2-Nitrophenyl)Ethan-1-One 1-(3-(Benzyloxy)Phenyl)Ethan-1-One 1-(3-Aminophenyl)Ethan-1-One 1-(3-Chlorophenyl)Ethan-1-One 1-(3-Fluorophenyl)Ethan-1-One 1-(3-Hydroxyphenyl)Ethan-1-One 1-(3-Iodophenyl)Ethan-1-One 1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One 1-(3-Methoxyphenyl)Ethan-1-One 1-(3-Nitrophenyl)Ethan-1-One 1-(3-Nitrophenyl)Propan-1-One 1-(4-(Benzyloxy)Phenyl)Ethan-1-One 1-(4-Fluorophenyl)Ethan-1-One 1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One 1-(Benzofuran-2-Yl)Ethan-1-One 1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One 1-(M-Tolyl)Ethan-1-One 1-(Naphthalen-2-Yl)Ethan-1-One 1-(O-Tolyl)Ethan-1-One 1-(Piperidin-1-Yl)Ethan-1-One 1-(Pyrazin-2-Yl)Ethan-1-One 1-(Pyridin-2-Yl)Ethan-1-One 1-(Pyridin-3-Yl)Ethan-1-One 1-(Pyridin-4-Yl)Ethan-1-One 1-(Pyrimidin-2-Yl)Ethan-1-One 1-(Pyrimidin-4-Yl)Ethan-1-One 1-(Pyrrolidin-1-Yl)Ethan-1-One 1-(Thiazol-2-Yl)Ethan-1-One 1-(Thiophen-2-Yl)Ethan-1-One 1-Aminoanthracene-9,10-Dione 1-Benzylindoline-2,3-Dione 1-Benzylpiperidin-3-One 1-Chloroanthracene-9,10-Dione 1-Hydroxyanthracene-9,10-Dione 1-Methylpiperazin-2-One 1-Methylpyrrolidin-2-One 1-Phenylbutan-1-One 1-Phenylpentan-1-One 1-Phenylpiperidin-2-One 1-Phenylpropan-2-One 2,2,2-Trifluoro-1-Phenylethan-1-One 2,2-Dimethyl-1-Phenylpropan-1-One 2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One 2,3,4,9-Tetrahydro-1H-Carbazol-1-One 2,3-Dihydrofuran-3-One 2,3-Dihydropyridin-2-One 2,5-Dichlorobenzoic Acid 2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One 2-Benzalacetophenone 2-Benzoylbenzoic Acid 2-Chloro-1-Phenylethan-1-One 2-Chlorocyclohexa-2,5-Diene-1,4-Dione 2-Chloroquinazolin-4(3H)-One 2-Hydroxy-1,2-Diphenylethan-1-One 2-Hydroxy-1-Phenylethan-1-One 2-Hydroxycyclohexa-2,5-Diene-1,4-Dione 2-Hydroxyquinolin-4(1H)-One 2-Methoxycyclohexa-2,5-Diene-1,4-Dione 2-Methyl-1-Phenylpropan-1-One 2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One 2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One 2-Methylcyclohexa-2,5-Diene-1,4-Dione 2-Methylcyclohexan-1-One 2-Methylisoindolin-1-One 2-Methylisoindoline-1,3-Dione 2-Methylpyridazin-3(2H)-One 2-Oxo-2-Phenylacetaldehyde 2-Oxo-2-Phenylacetic Acid 3,3-Difluoropiperidin-4-One 3,3-Dimethylcyclohexan-1-One 3,3-Dimethylpiperidin-4-One 3,4-Dihydroquinoxalin-2(1H)-One 3-Acetyl-2H-Chromen-2-One 3-Aminopyrrolidin-2-One 3-Bromo-1H-Pyrrole-2,5-Dione 3-Chloro-1-Phenylpropan-1-One 3-Fluoropiperidin-4-One 3-Hydroxy-2-Phenyl-4H-Chromen-4-One 3-Hydroxypyrrolidin-2-One 3-Methylcyclohexan-1-One 3-Methylene-2,3-Dihydro-1H-Inden-1-One 3-Methylpiperazin-2-One 3-Methylpyrimidin-4(3H)-One 3-Oxo-3-Phenylpropanenitrile 3-Oxo-N-Phenylbutanamide 3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One 3-Phenyl-2-Thioxoimidazolidin-4-One 3-Phenylacrylaldehyde 3-Phenylimidazolidine-2,4-Dione 4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione 4-(1,2,2-Triphenylvinyl)Benzaldehyde 4-(Hydroxymethyl)Pyrrolidin-2-One 4-Benzylmorpholin-3-One 4-Bromoisoindolin-1-One 4-Bromopyridazin-3(2H)-One 4-Chloro-1-Phenylbutan-1-One 4-Chloropyridazin-3(2H)-One 4-Fluoroindoline-2,3-Dione 4-Hydroxy-2H-Chromen-2-One 4-Hydroxydihydrofuran-2(3H)-One 4-Hydroxypiperidin-2-One 4-Hydroxypyrrolidin-2-One 4-Methyl-2H-Chromen-2-One 4-Methylisobenzofuran-1(3H)-One 4-Oxo-4-Phenylbutanoic Acid 4-Phenylbutan-2-One 4-Phenylcyclohexan-1-One 4-Phenylmorpholin-3-One 4-Phenylpyrrolidin-2-One 5,6-Dihydrobenzo[D]Thiazol-7(4H)-One 5-(Aminomethyl)Pyrrolidin-2-One 5-(Hydroxymethyl)Pyrrolidin-2-One 5-Bromoisoindolin-1-One 5-Bromoisoindoline-1,3-Dione 5-Bromopyrimidin-4(3H)-One 5-Chloroisoindoline-1,3-Dione 5-Chloropyrimidin-4(3H)-One 5-Chloropyrimidine-2,4(1H,3H)-Dione 5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 5-Fluorochroman-4-One 5-Fluoroindolin-2-One 5-Fluoroisoindolin-1-One 5-Fluoropyrimidin-4(3H)-One 5-Fluoropyrimidine-2,4(1H,3H)-Dione 5-Hydroxy-2-Phenyl-4H-Chromen-4-One 5-Hydroxypiperidin-2-One 5-Methoxy-2-Phenyl-4H-Chromen-4-One 5-Methyl-3,4-Dihydronaphthalen-1(2H)-One 5-Methylindolin-2-One 5-Oxopyrrolidine-2-Carboxylic Acid 6-Bromoisoindolin-1-One 6-Fluorochroman-4-One 6-Fluoroindoline-2,3-Dione 6-Fluoroisobenzofuran-1(3H)-One 6-Hydroxy-2,3-Dihydro-1H-Inden-1-One 6-Methoxy-2,3-Dihydro-1H-Inden-1-One 6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One 6-Methoxyisoindolin-1-One 6-Methyl-2,3-Dihydro-1H-Inden-1-One 7,8-Dihydroquinolin-5(6H)-One 7-(Diethylamino)-2H-Chromen-2-One 7-Bromo-3,4-Dihydronaphthalen-1(2H)-One 7-Bromochroman-4-One 7-Bromoindoline-2,3-Dione 7-Bromoquinazolin-4(3H)-One 7-Chloro-3,4-Dihydronaphthalen-1(2H)-One 7-Fluorochroman-4-One 7-Fluoroindolin-2-One 7-Fluoroquinazolin-4(3H)-One 7-Hydroxy-2H-Chromen-2-One 7-Methoxy-2H-Chromen-2-One 7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One 7-Methoxychroman-4-One 7-Methylindoline-2,3-Dione 8-Bromochroman-4-One 8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One 8-Fluoroisoquinolin-1(2H)-One 8-Methylchroman-4-One Acetophenone Azepan-2-One Benzo[Cd]Indol-2(1H)-One Benzofuran-2(3H)-One Chroman-2-One Cyclobutanone Cyclohex-2-En-1-One Cyclohexane-1,3-Dione Cyclopent-2-En-1-One Cyclopentane-1,3-Dione Dihydro-2H-Pyran-2,6(3H)-Dione Dihydrofuran-2,5-Dione Dihydrofuran-3(2H)-One Dihydrothiophen-3(2H)-One Ethene-1,1-Diyldibenzene Ethyl 2-Oxo-2-Phenylacetate Ethyl 3-Oxo-3-Phenylpropanoate Furan-2(5H)-One Isoquinolin-1-Ol Methyl 3-Oxo-3-Phenylpropanoate Morpholin-3-One Phenyl(3-(Trifluoromethyl)Phenyl)Methanone Phenyl(M-Tolyl)Methanone Phenyl(P-Tolyl)Methanone Phenyl(Pyridin-3-Yl)Methanone Phenyl(Thiophen-2-Yl)Methanone Piperidine-2,4-Dione Propiophenone Pyrimidine-4,6(1H,5H)-Dione Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (3-Oxocyclohexyl)Carbamate Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate Tert-Butyl 2-Oxopiperidine-1-Carboxylate Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate Tert-Butyl 4-Oxopiperidine-1-Carboxylate Tetrahydropyrimidin-2(1H)-One

By Key Group+−

2,2,2-Trichloro-Ethanone 2,2-Dihydroxy-Ethanone 2,2-Dimethylpropan-1-One 2-Amino-Ethanone 2-Bromoethanone 2-Chloroacetyl 2-Hydroxyethanone 2-Oxoacetaldehyde 2-Oxopropanoic Acid 3-(Dimethylamino)Prop-2-Enoyl 3-Buten-2-One 3-Chloro-1-Propanone 3-Oxo-Propanenitrile 3-Oxobutanamide 4,4,4-Trifluoro-1,3-Dione 4-Chloro-Butan-1-One 4-Oxo-Butanoic Acid 4-Oxobut-2-Enoic Acid 5-Oxo-Pentanoic Acid Acetylacetonate Acetylquinoline Benzofuran-One Benzoimidazol-One Benzophenone Benzorophenone Benzothiazole-Thione Benzoxazin-One Benzoxazol-One Benzoyl Bromindan-One Bromoethanone Butan-1-One Butan-2-One Butane-1,3-Dione Butanedione Butanedione Butanone Butanone Carbazol-One Carbonyl Cyanide Carbonyl-Phenyl-Boronic Acid Carbonyl-Phenyl-Boronic Acid/Ester Carbonyl-Phenyl-Boronic-Acid Chloro-Inden-One Chloro-One Chloroethanone Chloropropiophenone Chroman-One Chromanone Chromanone Chromen-One Dicarbonyl Dicarbonyl Dichloroacetophenone Dienone Diethanone Diethanone Difluoroacetophenone Dihydroxy-Chromen-One Dimethyl-Indanone Dimethylamino-Propan-1-One Dione Dioxobutanoate Dioxohexanoate Dioxopentanoate Dithione Dithione Enone Ethanone Ethyl 2,4-Dioxobutanoate Ethyl 2-Oxoacetate Ethyl 3-Oxopropanoate Fluoren-One Fluorobenzoyl Formylpiperazine Furan-One Heptanedionato Heptanedionato Hexafluoroacetylacetonato Hexan-1-One Hydroxyethanone Imidazolidin-One Imidazolidine-One Imidazopyridin-One Indanone Indazol-One Inden-One Indol-One Indolin-One Isonicotinoyl Isoquinolin-One Methoxy-Indanone Methyl 2,4-Dioxo-Butanoate Methyl 2-Oxoacetate Methyl 3-Oxopropanoate Methyl-Pyrazolone Morpholino-Methanone Morpholinone Naphthyridin-One Nicotinoyl-Chloride Oxadiazol-One Oxoacetaldehyde Oxoazepane Oxoazepane Oxochroman Oxopropionate Oxotetrahydro Pentan-1-One Phenyl-Chromen-One Phenyl-One Phthalazin-One Piperazin-One Piperidine-Methanone Piperidinone Prop-2-En-1-One Propan-1-One Propan-2-One Purin-One Pyran-One Pyrazin-One Pyrazol-One Pyrazolopyridin-One Pyridazin-One Pyridinone Pyrimidinone Pyrrolidinone Pyrrolopyridin-One Quinazolin-One Quinolinone Tetrahydropyran-One Tetraone Tetraone Thiazolidine-One Triazine-One Triazol-One Trifluoro-Ethanone Trifluoroacetophenone Trifluoroethanone Trifluoromethyl-Acetophenone Trifluoromethyl-Phenyl-One Trione

By Parent Nucleus+−

Acridines Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzodioxans Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Carbazoles Cinnolines Dioxolanes Epoxides Furans Imidazoles Indazoles Indoles Indolines Isoxazoles Morpholines Naphthyridines Non-Halogenated Heterocycles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazoles Oxazolidines Oxetanes Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydrofurans Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiazoles Thiazolidines Triazoles

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Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazones Iodides Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Thioesters Thiophenes Trifluoromethyls

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RC(=O)R'

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    1-(2-Fluoro-3-hydroxyphenyl)ethanone

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    A2950361191999-09-398%

    1-(2-Fluoro-3-hydroxyphenyl)ethanone

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    1-(2-Amino-3-hydroxyphenyl)ethanone

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    1-(2-Amino-3-hydroxyphenyl)ethanone

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    1-(5-Hydroxy-2-nitrophenyl)ethanone

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    1-(5-Hydroxy-2-nitrophenyl)ethanone

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    1-(2-Fluoro-5-hydroxyphenyl)ethanone

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    1-(2-Fluoro-5-hydroxyphenyl)ethanone

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    1-(2-Chloro-5-hydroxyphenyl)ethanone

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    1-(2-Chloro-5-hydroxyphenyl)ethanone

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    1-(5-Hydroxy-2-methoxyphenyl)ethanone

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    A83136431405-60-497%

    1-(5-Hydroxy-2-methoxyphenyl)ethanone

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    4'-Fluoro-3'-hydroxyacetophenone

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    4'-Fluoro-3'-hydroxyacetophenone

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    1-(2,4,5-Trihydroxyphenyl)ethanone

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    1-(2,4,5-Trihydroxyphenyl)ethanone

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    1-(2,3-Dihydroxyphenyl)ethanone

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    1-(2,3-Dihydroxyphenyl)ethanone

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    1-(3-Hydroxy-2-nitrophenyl)ethanone

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    1-(3-Hydroxy-2-nitrophenyl)ethanone

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    3,5-Dihydroxyacetophenone

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    3,5-Dihydroxyacetophenone

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    1-(5-Hydroxy-4-methoxy-2-methylphenyl)ethanone

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    1-(5-Hydroxy-4-methoxy-2-methylphenyl)ethanone

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    Methyl 4-acetyl-2-hydroxybenzoate

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    Methyl 4-acetyl-2-hydroxybenzoate

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    4-Acetyl-2-hydroxybenzoic acid

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    4-Acetyl-2-hydroxybenzoic acid

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    3-Hydroxy-4-methoxyacetophenone

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    3-Hydroxy-4-methoxyacetophenone

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    1-(3-Hydroxy-5-methylphenyl)ethanone

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    1-(3-Hydroxy-5-methylphenyl)ethanone

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    3-Hydroxyacetophenone

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    A100185121-71-198%

    3-Hydroxyacetophenone

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