Chemistry Heterocyclic Building Blocks Oxadiazoles

Oxadiazoles

Oxadiazoles belong to the azole family of heterocyclic aromatic compounds and have the molecular formula C2H2N2O. There exist four oxadiazole isomers, 1,2,3-isomer, 1,2,4-Oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole.

Several pharmaceutical drugs, including raltegravir, butalamine, fasiplon, oxolamine, and pleconaril, contain 1,2,4-oxadiazole, 1,2,5-oxadiazole, or 1,3,4-oxadiazole. The 1,2,3-isomer is prone to ring-opening and forms the diazoketone tautomer, but it can be found in the uncommon sydnone motif.

Oxadiazoles are used in two ways in pharmacology: as a crucial component of the pharmacophore or as a planar aromatic linker that positions substituents correctly and adjusts molecular properties.

There are various regioisomeric forms of oxadiazoles, which are organic heteroaromatic rings comprised of a five-membered structure with two nitrogen atoms and one oxygen atom.

Among the four isomers that exist, the 1,3,4-oxadiazole isomer is the most commonly utilized for diverse applications. The derivatives of 1,3,4-oxadiazole display a broad spectrum of biological properties, such as anti-cancer, anti-inflammatory, analgesic, anticonvulsant, and anti-HIV activities.

More >>

Further Reading:
>>
More Skeleton screening
✕ ✕ ✕ ✕ ✕ ✕

By Key Group+−

benzoxadiazole methyl-oxadiazole oxadiazo-pyridine oxadiazol-amide oxadiazol-one oxadiazole-carboxylate oxadiazole-carboxylic acid phenyl-oxadiazole

By Parent Nucleus+−

Aromatic Heterocycles Benzimidazoles Isoxazoles Other Aromatic Heterocycles Piperidines Pyridazines Pyrrolidines Triazoles

By Functional Group+−

Alcohols Amides Amidines Amines Aryls Benzyl bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Ketones Oximes Phenols Sulfones Trifluoromethyls

Framework+−

1,2,4-oxadiazole 1,2,5-oxadiazole 1,3,4-oxadiazole 2,5-diphenyl-1,3,4-oxadiazole 2-phenyl-1,3,4-oxadiazole 3-phenyl-1,2,4-oxadiazole benzo[c][1,2,5]oxadiazole

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    By Configuration+−

    2-((3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)thio)acetic acid

    click to sign in and save

    A1034746338746-11-595%

    2-((3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)thio)acetic acid

    $1446.00/5g

    Detail
    2-(5-Phenyl-1,2,4-oxadiazol-3-yl)morpholine hydrochloride

    click to sign in and save

    A10391131797716-80-395%

    2-(5-Phenyl-1,2,4-oxadiazol-3-yl)morpholine hydrochloride

    $259.00/250mg

    Detail
    Ethyl 2-(5-methyl-1,3,4-oxadiazol-2-yl)acetate

    click to sign in and save

    A10471965011-96-195%

    Ethyl 2-(5-methyl-1,3,4-oxadiazol-2-yl)acetate

    $120.00/250mg

    Detail
    Benzo[c][1,2,5]oxadiazole

    click to sign in and save

    A120288273-09-697%

    Benzo[c][1,2,5]oxadiazole

    $28.00/5g

    Detail
    2-((5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-yl)thio)-1-(indolin-1-yl)ethanone

    click to sign in and save

    A1218639571904-77-398%

    2-((5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-yl)thio)-1-(indolin-1-yl)ethanone

    $331.00/50mg

    Detail
    N-(4-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-2-(o-tolyloxy)acetamide

    click to sign in and save

    A1229370385389-39-998%

    N-(4-(5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-2-(o-tolyloxy)acetamide

    $184.00/10mg

    Detail
    2-(4-Chlorophenyl)-N-(4-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)acetamide

    click to sign in and save

    A1229371370854-75-498%

    2-(4-Chlorophenyl)-N-(4-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)acetamide

    $1850.00/100mg

    Detail
    2-(4-Chlorophenyl)-5-((quinazolin-4-yloxy)methyl)-1,3,4-oxadiazole

    click to sign in and save

    A1229438793722-88-098%

    2-(4-Chlorophenyl)-5-((quinazolin-4-yloxy)methyl)-1,3,4-oxadiazole

    $210.00/25mg

    Detail
    (4-Amino-1,2,5-oxadiazol-3-yl)methanol

    click to sign in and save

    A13917341092310-34-398%

    (4-Amino-1,2,5-oxadiazol-3-yl)methanol

    $976.00/1g

    Detail
    Ethyl 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-carboxylate

    click to sign in and save

    A1432944151097-76-698%

    Ethyl 5-(4-nitrophenyl)-1,3,4-oxadiazole-2-carboxylate

    $330.00/250mg

    Detail
    Lithium 3-phenyl-1,2,4-oxadiazole-5-carboxylate

    click to sign in and save

    A14800281864062-88-398%

    Lithium 3-phenyl-1,2,4-oxadiazole-5-carboxylate

    $162.00/250mg

    Detail
    3-(4-Bromophenyl)-1,2,4-oxadiazole-5-carboxylic acid

    click to sign in and save

    A1563602944906-44-998%

    3-(4-Bromophenyl)-1,2,4-oxadiazole-5-carboxylic acid

    $395.00/100mg

    Detail
    2-(4-Methoxyphenyl)-5-(1-methyl-1H-indol-3-yl)-1,3,4-oxadiazole

    click to sign in and save

    A1598787511239-29-597%

    2-(4-Methoxyphenyl)-5-(1-methyl-1H-indol-3-yl)-1,3,4-oxadiazole

    $809.00/100mg

    Detail
    4-(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)aniline

    click to sign in and save

    A161766696898-45-295%

    4-(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)aniline

    $67.00/100mg

    Detail
    4,7-Dibromobenzo[c][1,2,5]oxadiazole

    click to sign in and save

    A16541154286-63-497%

    4,7-Dibromobenzo[c][1,2,5]oxadiazole

    $1192.00/25g

    Detail
    2,5-Di(naphthalen-1-yl)-1,3,4-oxadiazole

    click to sign in and save

    A275307905-62-498%

    2,5-Di(naphthalen-1-yl)-1,3,4-oxadiazole

    $58.00/1g

    Detail
    2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

    click to sign in and save

    A29322315420-02-797%

    2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

    $18.00/250mg

    Detail
    2,5-Diphenyl-1,3,4-oxadiazole

    click to sign in and save

    A336134725-12-298+%

    2,5-Diphenyl-1,3,4-oxadiazole

    $53.00/5g

    Detail
    2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid

    click to sign in and save

    A76724555151-91-295%

    2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid

    $188.00/1g

    Detail
    4-Benzofurazancarboxaldehyde

    click to sign in and save

    A79412432863-32-498%

    4-Benzofurazancarboxaldehyde

    $16.00/250mg

    Detail
    1 2 3 4 5 6 7 8 9 ...    page 1 of 178 Pages

    Inquiry