Home Chemistry Heterocyclic Building Blocks Indazoles 6-Nitro-1H-Indazole
Reduction: The nitro group can be reduced to the corresponding amino group using reducing agents such as hydrogen gas over a metal catalyst, or tin and hydrochloric acid.
Nucleophilic Substitution: The nitro group can undergo nucleophilic substitution reactions with nucleophiles such as hydrazine. hydroxylamine, or thiols to form corresponding substituted products.
Reductive Amination: The nitro group can be reduced to the amino group, which can subsequently undergo reductive amination with carbonyl compounds to form secondary or tertiary amines.
Cyclization Reactions: It can participate in cyclization reactions with appropriate nucleophiles or electrophiles to form fused heterocyclic compounds or other cyclic structures.
Functional Group Interconversion: The nitro group can be converted to other functional groups such as amino, hydroxyl, or azide groups through appropriate chemical transformations.
Nitration: The aromatic ring can undergo nitration reactions with nitric acid or a mixture of nitric and sulfuric acids to introduce additional nitro groups.
Oxidation: The indazole ring can be oxidized under appropriate conditions to form various oxidation products such as N-oxides or other oxidized derivatives.
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