Home Chemistry Organic Building Blocks Fluorinated Building Blocks 2-Fluoroaniline
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—NH2).
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
Reimer-Tiemann Reaction: Aniline can react with chloroform (CHCl3) and a base to undergo the Reimer-Tiemann reaction, leading to the formation of a salicylaldehyde derivative.
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Methyl 2,4-diamino-3-fluoro-5-nitrobenzoate
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2,4-Difluoro-5-(trifluoromethoxy)aniline
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2-Amino-4-bromo-3-fluoro-5-iodobenzamide
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