Home Chemistry Organic Building Blocks Chlorides 2-Chloro-6-Nitroaniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—NH2,—NO2).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Coupling Reactions: Aniline can participate in coupling reactions, such as Ullmann coupling, Buchwald-Hartwig coupling, and others, to form C-N bonds with various partner molecules.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.
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Methyl 4-amino-5-chloro-2-methoxy-3-nitrobenzoate
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Methyl 4-amino-3-chloro-5-nitrobenzoate
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