Home Chemistry Heterocyclic Building Blocks Indazoles 1H-Indazol-6-Amine
Substitution Reactions: The amino group can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of substituted amines.
Alkylation: The nitrogen atom in the indazole ring can be alkylated by reaction with alkyl halides or sulfonates.
Acylation: The nitrogen atom in the indazole ring can undergo acylation reactions to form N-acyl derivatives.
Reduction: The imine group can be reduced to the corresponding amine using reducing agents such as sodium borohydride or hydrogen gas over a metal catalyst.
Ring-closure Reactions: The indazole ring can participate in ring-closure reactions under specific conditions, leading to the formation of cyclic compounds.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Protonation: The amine group can be protonated under acidic conditions to form the corresponding ammonium salt.
Dehydration: Under appropriate conditions, dehydration reactions can occur to eliminate water and form unsaturated compounds.
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