Platelet-activating factor receptor (PAFR) is a member of the G protein-coupled receptor family, with seven transmembrane domains. It is widely distributed in various cells and tissues, such as leukocytes, platelets, lungs, and the heart. PAFR participates in regulating biological responses such as inflammation, platelet aggregation, and vascular permeability by recognizing platelet-activating factor (PAF). It activates multiple signaling pathways, including IP3, DAG, and cAMP. Mutations or abnormal expression of PAFR are associated with the development of asthma, cardiovascular diseases, and inflammatory disorders.