Home Chemistry Heterocyclic Building Blocks Morpholines Benzyl Morpholine-4-Carboxylate
Hydrolysis: The carboxylate functional group is susceptible to hydrolysis in the presence of water or an acidic or basic medium. This would lead to the cleavage of the carboxylate group and the formation of the corresponding acid and alcohol.
Esterification: Benzyl morpholine-4-carboxylate can react with an alcohol and an acid catalyst to form an ester, replacing the carboxylate group with an ester functional group.
Reduction: The carbonyl group in the carboxylate can be reduced to an alcohol, typically using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Acylation: The benzyl group can be substituted with other acyl groups under suitable conditions, such as with an acyl chloride in the presence of a Lewis acid catalyst.
Nucleophilic Substitution: Depending on the conditions and the presence of nucleophiles, substitution reactions may occur at various positions of the morpholine ring or the benzyl group.
Oxidation: The benzyl group can be oxidized to a benzaldehyde or further to a benzoic acid using strong oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4).
Grignard Reaction: The benzyl group can react with a Grignard reagent to form a new carbon-carbon bond.
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(S)-Benzyl 2-(aminomethyl)morpholine-4-carboxylate hydrochloride
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Benzyl 3-(aminomethyl)morpholine-4-carboxylate hydrochloride
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