The Liver X Receptor (LXR) family is part of the nuclear receptor superfamily, comprising two main members: LXRα and LXRβ. LXRα is primarily expressed in the liver, adipose tissue, kidneys, and intestines, while LXRβ is widely expressed in various tissues throughout the body. LXRs regulate cholesterol, lipid metabolism, and inflammatory responses by sensing oxysterols derived from cholesterol. They promote reverse cholesterol transport, reduce LDL levels in the bloodstream, and regulate fatty acid synthesis pathways. Activation of LXRs plays a crucial role in maintaining metabolic homeostasis and immune responses. The specificity of gene expression and mutations in LXRs are associated with various metabolic disorders, cardiovascular diseases, and inflammatory conditions.