Home Chemistry Heterocyclic Building Blocks Pyridines Pyridin-3-Ylmethanamine
Acylation: Pyridin-3-ylmethanamine can undergo acylation reactions, where the amino group is replaced by an acyl group (-COCH3, -COCl, etc.). This can be achieved through reactions with acyl chlorides or acid anhydrides in the presence of a base.
Alkylation/Acylation: The amine group can undergo alkylation or acylation reactions, where an alkyl or acyl group is introduced onto the nitrogen atom. This can be achieved using alkyl halides or acyl halides in the presence of a base.
Reductive Amination: Pyridin-3-ylmethanamine can undergo reductive amination reactions, where the amino group is used to attach another molecule (typically an aldehyde or ketone) under reducing conditions, forming a secondary amine.
Substitution Reactions: The pyridine ring can undergo substitution reactions such as nucleophilic aromatic substitution (SNAr) or electrophilic aromatic substitution (SEAr). For instance, the nitrogen atom can act as a nucleophile attacking electrophilic aromatic systems, or the ring can be functionalized by electrophilic reagents like acyl chlorides or nitration agents.
Redox Reactions: Depending on the conditions, pyridin-3-ylmethanamine can undergo redox reactions, especially considering the presence of the nitrogen atom that can act as a potential site for oxidation or reduction.
Condensation Reactions: Pyridin-3-ylmethanamine can participate in condensation reactions, such as the formation of imines or Schiff bases, by reacting with carbonyl compounds.
Protonation/Deprotonation: As a basic compound due to the amine group, pyridin-3-ylmethanamine can undergo protonation/deprotonation reactions, where it accepts or donates protons, respectively.
Metal Complexation: The nitrogen atom in the pyridine ring can coordinate with metal ions to form complexes, leading to various coordination chemistry reactions.
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(6-Methoxypyridin-3-yl)methanamine dihydrochloride
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(6-Bromopyridin-3-yl)methanamine dihydrochloride
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3-(Aminomethyl)-6-(trifluoromethyl)pyridine
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(6-(Trifluoromethyl)pyridin-3-yl)methanamine dihydrochloride
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Methyl 5-(aminomethyl)picolinate dihydrochloride
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(2-(Trifluoromethyl)pyridin-3-yl)methanamine
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(6-Bromo-4-(trifluoromethyl)pyridin-3-yl)methanamine
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(5-Bromopyridin-3-yl)methanamine dihydrochloride
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tert-Butyl ((5-(aminomethyl)pyridin-2-yl)methyl)carbamate
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