Home Chemistry Heterocyclic Building Blocks Pyridines 2-(Chloromethyl)Pyridine
Nucleophilic substitution: The chlorine atom can be substituted by a nucleophile, such as amines or thiols, leading to the formation of corresponding substituted pyridine derivatives.
Palladium-catalyzed cross-coupling reactions: The chloromethyl group can undergo cross-coupling reactions with various nucleophiles, such as aryl or vinyl boronic acids, to form biaryl or bivinyl compounds.
Nucleophilic aromatic substitution: The pyridine ring can undergo nucleophilic aromatic substitution reactions with strong nucleophiles, such as amines or alkoxides, leading to substitution of the chloromethyl group with the nucleophile.
Addition reactions: The chloromethyl group can undergo addition reactions with nucleophiles, such as Grignard reagents or organolithium compounds, to form addition products.
Oxidation reactions: The chloromethyl group can be oxidized to form aldehydes or carboxylic acids under appropriate conditions.
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2,6-Bis(chloromethyl)pyridine hydrochloride
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4-Chloro-2-(chloromethyl)-5-methoxypyridine
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5-Bromo-2-(chloromethyl)pyridine hydrochloride
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5-Chloro-2-(chloromethyl)pyridine hydrochloride
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5-Chloro-2-(chloromethyl)-3-fluoropyridine
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5-Bromo-2-(chloromethyl)-3-fluoropyridine
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5-Chloro-2-(chloromethyl)-3-(trifluoromethyl)pyridine
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