Home Chemistry Organic Building Blocks Iodides 1-Fluoro-3-Iodobenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —I,—F).
Cross-Coupling Reactions: Iodobenzene is commonly used in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling an aryl halide (like iodobenzene) with an organometallic reagent, leading to the formation of new carbon-carbon bonds.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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