Home Chemistry Organic Building Blocks Bromides 1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—CF3).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Oxidation: Oxidation reactions could lead to the conversion of the trifluoromethyl group to a carbonyl group (e.g., trifluoromethyl ketone).
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1-Bromo-2,4-difluoro-3-(trifluoromethyl)benzene
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1-Bromo-2-fluoro-5-nitro-3-(trifluoromethyl)benzene
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3-Bromo-4-fluoro-5-(trifluoromethyl)aniline
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