Home Chemistry Heterocyclic Building Blocks Thiophenes Phenyl(Thiophen-2-Yl)Methanone
Reduction: The ketone functional group can be reduced to an alcohol using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Friedel-Crafts Acylation: The ketone can undergo Friedel-Crafts acylation reactions with Lewis acids, resulting in the introduction of an alkyl or acyl group onto the aromatic ring.
Nucleophilic Addition: The ketone carbon is electrophilic, making it susceptible to nucleophilic attack. For example, in the presence of a strong nucleophile, such as a primary amine, an imine or enamine can form.
Oxidation Reactions: Depending on the conditions, the compound may undergo further oxidation, potentially converting the ketone to a carboxylic acid or other oxidized products.
Suzuki-Miyaura Cross-Coupling: If the compound has a suitable leaving group, it can undergo Suzuki-Miyaura cross-coupling reactions with boronic acids or boronate esters.
Ring-Closing Reactions: If there are reactive functional groups present, such as alkenes or amines, they may participate in ring-closing reactions under appropriate conditions.
Substitution Reactions: If there are reactive positions (such as halogens) on the aromatic rings, they can undergo substitution reactions.
Heterocyclization: The presence of a thiophene ring provides the potential for heterocyclization reactions with appropriate reagents.
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(5-Bromothiophen-2-yl)(phenyl)methanone
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