Chemistry Organic Building Blocks Trifluoromethyls 2-(Trifluoromethyl)Benzamide

2-(Trifluoromethyl)Benzamide

These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —CF3,—C(O)NH2).

Reduction: The trifluoromethyl group could potentially be reduced to a methyl group or a difluoromethyl group under certain reaction conditions.
Hofmann Rearrangement: Benzamide can undergo Hofmann rearrangement when treated with chlorine or bromine in the presence of a strong base, resulting in the conversion of the amide group to an 【isocyanate|https://www.ambeed.com/isocyanates-and-isothiocyanates.html】 group. Further hydrolysis of the isocyanate can yield an amine with one fewer carbon atom.

Further Reading:

Framework+−

(2,2,2-Trifluoroethoxy)Benzene (2-(Trifluoromethoxy)Phenyl)Boronic Acid (2-(Trifluoromethyl)Phenyl)Boronic Acid (2-(Trifluoromethyl)Phenyl)Methanol (2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (3-(Trifluoromethoxy)Phenyl)Boronic Acid (3-(Trifluoromethoxy)Phenyl)Methanol (3-(Trifluoromethyl)Phenyl)Boronic Acid (3-(Trifluoromethyl)Phenyl)Methanol (4-(Trifluoromethyl)Phenyl)Boronic Acid (Perfluoropropane-2,2-Diyl)Dibenzene (Trifluoromethyl)Benzene 1,3-Bis(Trifluoromethyl)Benzene 1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One 1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine 1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine 1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine 1-(Bromomethyl)-2-(Trifluoromethyl)Benzene 1-(Bromomethyl)-3-(Trifluoromethyl)Benzene 1-Bromo-2-(Trifluoromethoxy)Benzene 1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene 1-Bromo-3-(Trifluoromethyl)Benzene 1-Chloro-2-(Trifluoromethoxy)Benzene 1-Chloro-2-(Trifluoromethyl)Benzene 1-Chloro-3-(Trifluoromethoxy)Benzene 1-Chloro-3-(Trifluoromethyl)Benzene 1-Chloro-4-(Trifluoromethoxy)Benzene 1-Fluoro-2-(Trifluoromethoxy)Benzene 1-Fluoro-2-(Trifluoromethyl)Benzene 1-Fluoro-3-(Trifluoromethyl)Benzene 1-Fluoro-4-(Trifluoromethoxy)Benzene 1-Fluoro-4-(Trifluoromethyl)Benzene 1-Iodo-2-(Trifluoromethyl)Benzene 1-Iodo-3-(Trifluoromethyl)Benzene 1-Methoxy-2-(Trifluoromethyl)Benzene 1-Methoxy-3-(Trifluoromethoxy)Benzene 1-Methoxy-3-(Trifluoromethyl)Benzene 1-Methoxy-4-(Trifluoromethyl)Benzene 1-Methyl-2-(Trifluoromethoxy)Benzene 1-Methyl-2-(Trifluoromethyl)Benzene 1-Methyl-3-(Trifluoromethyl)Benzene 1-Nitro-2-(Trifluoromethoxy)Benzene 1-Nitro-2-(Trifluoromethyl)Benzene 1-Nitro-3-(Trifluoromethoxy)Benzene 1-Nitro-3-(Trifluoromethyl)Benzene 1-Phenoxy-3-(Trifluoromethyl)Benzene 1-Phenoxy-4-(Trifluoromethyl)Benzene 1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole 2,2,2-Trifluoro-1-Phenylethan-1-Amine 2,2,2-Trifluoro-1-Phenylethan-1-Ol 2,2,2-Trifluoro-1-Phenylethan-1-One 2-(2,2,2-Trifluoroethoxy)Pyridine 2-(Trifluoromethoxy)Aniline 2-(Trifluoromethoxy)Benzaldehyde 2-(Trifluoromethoxy)Benzoic Acid 2-(Trifluoromethoxy)Benzonitrile 2-(Trifluoromethoxy)Phenol 2-(Trifluoromethoxy)Pyridine 2-(Trifluoromethyl)-1,1'-Biphenyl 2-(Trifluoromethyl)Aniline 2-(Trifluoromethyl)Benzaldehyde 2-(Trifluoromethyl)Benzamide 2-(Trifluoromethyl)Benzoic Acid 2-(Trifluoromethyl)Benzonitrile 2-(Trifluoromethyl)Phenol 2-(Trifluoromethyl)Pyrazine 2-(Trifluoromethyl)Pyridine 2-(Trifluoromethyl)Pyrimidine 2-(Trifluoromethyl)Quinazoline 2-(Trifluoromethyl)Thiazole 2-(Trifluoromethyl)Thiophene 2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene 2-Bromo-4-(Trifluoromethyl)Aniline 2-Bromo-6-(Trifluoromethyl)Aniline 2-Chloro-3-(Trifluoromethyl)Aniline 2-Chloro-4-(Trifluoromethyl)Pyrimidine 2-Chloro-6-(Trifluoromethyl)Aniline 2-Methoxy-3-(Trifluoromethyl)Pyridine 2-Methoxy-5-(Trifluoromethyl)Pyridine 2-Phenoxy-5-(Trifluoromethyl)Pyridine 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine 3-(Trifluoromethoxy)Aniline 3-(Trifluoromethoxy)Benzaldehyde 3-(Trifluoromethoxy)Benzoic Acid 3-(Trifluoromethoxy)Benzonitrile 3-(Trifluoromethoxy)Phenol 3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine 3-(Trifluoromethyl)Aniline 3-(Trifluoromethyl)Benzaldehyde 3-(Trifluoromethyl)Benzenesulfonyl Chloride 3-(Trifluoromethyl)Benzoic Acid 3-(Trifluoromethyl)Benzonitrile 3-(Trifluoromethyl)Phenol 3-(Trifluoromethyl)Pyridazine 3-(Trifluoromethyl)Pyridin-2-Ol 3-(Trifluoromethyl)Pyridine 3-Chloro-4-(Trifluoromethyl)Aniline 4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione 4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane 4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane 4-(Trifluoromethoxy)Aniline 4-(Trifluoromethyl)-2H-Chromen-2-One 4-(Trifluoromethyl)Phenol 4-(Trifluoromethyl)Pyridine 4-(Trifluoromethyl)Pyrimidin-2-Amine 4-(Trifluoromethyl)Pyrimidine 4-(Trifluoromethyl)Thiazole 4-Bromo-3-(Trifluoromethyl)Aniline 5-(Trifluoromethyl)Pyridin-2-Amine 5-(Trifluoromethyl)Pyridin-2-Ol 6-(Trifluoromethyl)-1H-Indazole 6-(Trifluoromethyl)-1H-Indole 6-(Trifluoromethyl)Pyridin-2-Amine 6-(Trifluoromethyl)Pyridin-3-Amine Methyl 2-(Trifluoromethyl)Benzoate Methyl 3-(Trifluoromethyl)Benzoate N-Phenyl-4-(Trifluoromethyl)Aniline Phenyl(3-(Trifluoromethyl)Phenyl)Methanone Phenyl(Trifluoromethyl)Sulfane

By Key Group+−

(R)-2,2,2-Trifluoro-1-Ethanamine (S)-2,2,2-Trifluoro-1-Ethanamine (Trifluoromethyl)Thio 1,1,1,3,3,3-Hexafluoropropan-2-Ol 2,2,2-Trifluoro Ethanamine 2,2,2-Trifluoro Ethanol 2,2,2-Trifluoroacetamido 2,2,2-Trifluoroethoxy 2,2,2-Trifluoroethyl 4,4,4-Trifluoro-1,3-Dione Bistrifluoromethyl Bromo-Trifluoromethyl-Pyrazole Bromo-Trifluoromethyl-Pyridine Bromo-Trifluoromethyl-Pyrimidine Bromo-Trifluoromethyl-Quinoline Bromobenzotrifluoride Chloro-Iodo-Trifluoromethyl-Pyridine Chloro-Trifluoromethyl-Pyridin-Amine Chloro-Trifluoromethyl-Pyridine Chloro-Trifluoromethyl-Pyrimidine Chloro-Trifluoromethyl-Quinoline Chlorobenzotrifluoride Fluoro-Trifluoromethyl-Pyridine Fluorobenzotrifluoride Hydroxy-Trifluoromethyl Iodo-Trifluoromethyl-Pyridine Iodobenzotrifluoride Methoxy-Trifluoromethyl-Benzene Methoxy-Trifluoromethyl-Pyridine Nitro-Trifluoromethyl-Benzene Nitro-Trifluoromethyl-Pyridin Trifluoro-Ethanone Trifluoroacetic Trifluoromethanamine Trifluoromethyl-Acetophenone Trifluoromethyl-Amine Trifluoromethyl-Benzene-Sulfonyl Chloride Trifluoromethyl-Benzimidazole Trifluoromethyl-Benzo Trifluoromethyl-Benzothiazole Trifluoromethyl-Benzothiophene Trifluoromethyl-Benzoxazole Trifluoromethyl-Benzyl Trifluoromethyl-Chroman Trifluoromethyl-Cinnamic-Acid Trifluoromethyl-Furan Trifluoromethyl-Hydroxy-Quinoline Trifluoromethyl-Imidazo Trifluoromethyl-Imidazole Trifluoromethyl-Imidazopyridine Trifluoromethyl-Indazole Trifluoromethyl-Indene Trifluoromethyl-Indole Trifluoromethyl-Indoline Trifluoromethyl-Isoquinoline Trifluoromethyl-Nicotinate Trifluoromethyl-Nicotinic Acid Trifluoromethyl-Oxazole Trifluoromethyl-Phenyl-Acetate Trifluoromethyl-Phenyl-Borate Trifluoromethyl-Phenyl-Boronic Acid Trifluoromethyl-Phenyl-Ethanamine Trifluoromethyl-Phenyl-Ethanol Trifluoromethyl-Phenyl-Ethylamine Trifluoromethyl-Phenyl-Hydrazine Trifluoromethyl-Phenyl-Hydrochloride Trifluoromethyl-Phenyl-Methanamine Trifluoromethyl-Phenyl-Methanol Trifluoromethyl-Phenyl-Morpholine Trifluoromethyl-Phenyl-One Trifluoromethyl-Phenyl-Phosphino Trifluoromethyl-Phenyl-Piperazin Trifluoromethyl-Phenyl-Piperidine Trifluoromethyl-Phenyl-Propanol Trifluoromethyl-Phenyl-Pyrazin Trifluoromethyl-Phenyl-Pyrazol Trifluoromethyl-Phenyl-Pyrimidin Trifluoromethyl-Phenyl-Pyrrolidine Trifluoromethyl-Phenyl-Thiazole Trifluoromethyl-Phenyl-Urea Trifluoromethyl-Picolinamide Trifluoromethyl-Piperazine Trifluoromethyl-Piperidine Trifluoromethyl-Pyrazine Trifluoromethyl-Pyrazol-Amide Trifluoromethyl-Pyrazole Trifluoromethyl-Pyrazolone Trifluoromethyl-Pyridazine Trifluoromethyl-Pyridin-Amine Trifluoromethyl-Pyridin-Methanol Trifluoromethyl-Pyridine-Ethylamine Trifluoromethyl-Pyridyl-Methanamine Trifluoromethyl-Pyrimidin-Amine Trifluoromethyl-Pyrimidin-Ol Trifluoromethyl-Pyrrolo Trifluoromethyl-Quinazoline Trifluoromethyl-Quinolin-Amine Trifluoromethyl-Quinoxaline Trifluoromethyl-Sulfonyl Trifluoromethyl-Tetrahydroisoquinoline Trifluoromethyl-Thiazol Trifluoromethyl-Thio Trifluoromethyl-Thiophene Trifluoromethylaniline Trifluoromethylphenol Trifluoromethylphenyl Trifluoromethylpyridine Trifluoromethylpyridine-Indenoxazole Trifluoromethylpyrimidine Trifluoromethylquinoline Trifluoromethylsulfonyl Trifluorotoluene-Dioxaborane

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzothiazoles Epoxides Furans Guanidines Imidazoles Imidazolines Indazoles Indoles Indolines Morpholines Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazoles Piperazines Piperidines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Spiroes Tetrahydroisoquinolines Tetrahydropyrans Thiazoles Thiazolidines Thiophenols Triazines Triazoles

By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amidines Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Thioesters Thiophenes Thioureas Ureas

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