Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-4-Iodopyridine
Substitution Reactions: The bromine and chlorine atoms are both potential leaving groups, allowing for substitution reactions with various nucleophiles or electrophiles.
Nucleophilic Aromatic Substitution (SNAr): The electron-deficient nature of the pyridine ring makes it susceptible to nucleophilic attack at the 2-position, leading to substitution reactions.
Metalation: The pyridine ring can be metalated at the 2-position, providing a platform for further functionalization reactions.
Cross-coupling Reactions: The bromine and chlorine atoms can serve as reactive sites for palladium-catalyzed cross-coupling reactions with suitable partners, such as organometallic reagents or aryl boronic acids.
Oxidation/Reduction Reactions: The functional groups present in 4-bromo-2-chloropyridine can undergo oxidation or reduction under appropriate conditions, leading to the formation of different products.
Cyclization Reactions: 4-bromo-2-chloropyridine can participate in cyclization reactions to form fused heterocyclic compounds or other cyclic structures.
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tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate
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2-Chloro-5-(trifluoromethyl)-4-iodopyridine
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2-Chloro-4-iodo-6-(trifluoromethyl)pyridine
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2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
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