Home Chemistry Heterocyclic Building Blocks Indazoles 5-Bromo-1H-Indazole
Substitution Reactions: The bromine atom can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution, leading to the formation of substituted indazoles.
Cross-Coupling Reactions: The bromine atom can participate in cross-coupling reactions, such as Suzuki coupling or Stille coupling, to form biaryl compounds.
Nucleophilic Addition: The bromine atom can undergo nucleophilic addition reactions with electron-deficient alkenes or alkynes, leading to the formation of bromoindazole derivatives.
Reduction: The bromine atom can be reduced to form the corresponding bromide or substituted indazole using reducing agents such as sodium borohydride or hydrogen gas over a metal catalyst.
Halogenation: The indazole ring can undergo further halogenation reactions under appropriate conditions, leading to the formation of di- or polyhalogenated indazoles.
Functional Group Transformation: The bromine atom can be replaced with other functional groups through substitution or elimination reactions, leading to the formation of diverse chemical structures.
Cyclization Reactions: The bromoindazole compound can participate in various cyclization reactions to form fused or bridged heterocyclic compounds.
Oxidation: The bromoindazole compound can undergo oxidation reactions to form the corresponding indazole N-oxide or other oxidized derivatives.
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