Chemistry Heterocyclic Building Blocks Furans
Furan is an organic compound with a five-membered aromatic ring comprised of four carbon atoms and one oxygen atom. Compounds that possess these ring structures are also known as furans.
In industrial settings, furan is produced through the palladium-catalyzed decarbonylation of furfural or the copper-catalyzed oxidation of 1,3-butadiene. In a laboratory setting, furan can be derived from furfural by oxidizing it to 2-furoic acid and subsequently undergoing decarboxylation.
Furan exhibits aromaticity due to the delocalization of one of the lone pairs of electrons from the oxygen atom into the ring. This results in a 4n + 2 aromatic system, following Hückel's rule, which is analogous to benzene.
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Furan-2-yl(piperazin-1-yl)methanone hydrochloride
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5-Bromo-N-(furan-2-ylmethyl)pyrimidin-2-amine