The PI3K (Phosphoinositide 3-kinase) family is divided into three classes: I, II, and III, composed of regulatory and catalytic subunits. These kinases are primarily located on the cell membrane, generating secondary messengers through phosphorylation of phosphoinositides, thereby regulating cell proliferation, survival, migration, and metabolism. In particular, Class I PI3K plays a critical role in the AKT/PKB signaling pathway, responding to growth factors and extracellular signals. PI3K is expressed in various tissues, and abnormalities in its activity and gene mutations are associated with various diseases, including cancer, inflammation, and metabolic disorders. Changes and mutations in specific gene expression have significant implications for cellular function and disease development.