CXCR| Ambeed

Inhibitors/Agonists Immunology/Inflammation CXCR

CXCR

: CXCR is a part of the chemokine receptor family, primarily mediating signal transduction through G protein-coupled receptors. Members of this family are expressed in various cells and tissues, regulating cell migration, inflammatory responses, and immune surveillance. The structure of CXCR includes seven transmembrane regions, with the N-terminus exposed externally for ligand binding. They are highly expressed in immune system cells such as T cells, B cells, and macrophages, participating in chemotaxis, cell adhesion, and pathway activation. The expression of CXCR genes is tissue-specific, and mutations may lead to immune deficiencies, excessive inflammatory responses, and tumor development.

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