Chemistry
Heterocyclic Building Blocks
Thiazoles
Thiazole, also known as 1,3-thiazole, is a type of heterocyclic compound that includes both nitrogen and sulfur atoms. It has a molecular formula of C3H3NS and is a pale yellow liquid possessing a scent reminiscent of pyridine.
There are multiple laboratory techniques available for the organic synthesis of thiazoles, with the most notable being the Hantzsch thiazole synthesis, which involves a reaction between haloketones and thioamides.
Thiazole rings exhibit planarity and aromaticity, with more extensive pi-electron delocalization than their oxazole counterparts, resulting in greater aromaticity for thiazoles.
Thiazoles find applications in peptide research and serve as a fundamental component in biologically active natural products such as thiamine (vitamin B1), bacitracin, and the penicillins, as well as in a wide range of synthetic drugs, dyes, and industrial chemicals.
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2-Bromo-4-methylthiazole-5-carbaldehyde
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2-(Trifluoromethyl)thiazole-5-carbaldehyde
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4,4'-(Thiazolo[5,4-d]thiazole-2,5-diyl)dibenzaldehyde
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2-(4,5-Dimethylthiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium bromide
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2-(4,5-Dimethylthiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium bromide
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