Chemistry Organic Building Blocks Trifluoromethyls 4-(Trifluoromethyl)Phenol

4-(Trifluoromethyl)Phenol

These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —CF3,—OH).

Reduction: The trifluoromethyl group could potentially be reduced to a methyl group or a difluoromethyl group under certain reaction conditions.
Fries Rearrangement: Phenol can undergo the Fries rearrangement when treated with a Lewis acid catalyst, leading to the migration of an acyl group within the molecule.

Further Reading:

Framework+−

(2,2,2-Trifluoroethoxy)Benzene (2-(Trifluoromethoxy)Phenyl)Boronic Acid (2-(Trifluoromethyl)Phenyl)Boronic Acid (2-(Trifluoromethyl)Phenyl)Methanol (2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (3-(Trifluoromethoxy)Phenyl)Boronic Acid (3-(Trifluoromethoxy)Phenyl)Methanol (3-(Trifluoromethyl)Phenyl)Boronic Acid (3-(Trifluoromethyl)Phenyl)Methanol (4-(Trifluoromethyl)Phenyl)Boronic Acid (Perfluoropropane-2,2-Diyl)Dibenzene (Trifluoromethyl)Benzene 1,3-Bis(Trifluoromethyl)Benzene 1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One 1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine 1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine 1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine 1-(Bromomethyl)-2-(Trifluoromethyl)Benzene 1-(Bromomethyl)-3-(Trifluoromethyl)Benzene 1-Bromo-2-(Trifluoromethoxy)Benzene 1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene 1-Bromo-3-(Trifluoromethyl)Benzene 1-Chloro-2-(Trifluoromethoxy)Benzene 1-Chloro-2-(Trifluoromethyl)Benzene 1-Chloro-3-(Trifluoromethoxy)Benzene 1-Chloro-3-(Trifluoromethyl)Benzene 1-Chloro-4-(Trifluoromethoxy)Benzene 1-Fluoro-2-(Trifluoromethoxy)Benzene 1-Fluoro-2-(Trifluoromethyl)Benzene 1-Fluoro-3-(Trifluoromethyl)Benzene 1-Fluoro-4-(Trifluoromethoxy)Benzene 1-Fluoro-4-(Trifluoromethyl)Benzene 1-Iodo-2-(Trifluoromethyl)Benzene 1-Iodo-3-(Trifluoromethyl)Benzene 1-Methoxy-2-(Trifluoromethyl)Benzene 1-Methoxy-3-(Trifluoromethoxy)Benzene 1-Methoxy-3-(Trifluoromethyl)Benzene 1-Methoxy-4-(Trifluoromethyl)Benzene 1-Methyl-2-(Trifluoromethoxy)Benzene 1-Methyl-2-(Trifluoromethyl)Benzene 1-Methyl-3-(Trifluoromethyl)Benzene 1-Nitro-2-(Trifluoromethoxy)Benzene 1-Nitro-2-(Trifluoromethyl)Benzene 1-Nitro-3-(Trifluoromethoxy)Benzene 1-Nitro-3-(Trifluoromethyl)Benzene 1-Phenoxy-3-(Trifluoromethyl)Benzene 1-Phenoxy-4-(Trifluoromethyl)Benzene 1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole 2,2,2-Trifluoro-1-Phenylethan-1-Amine 2,2,2-Trifluoro-1-Phenylethan-1-Ol 2,2,2-Trifluoro-1-Phenylethan-1-One 2-(2,2,2-Trifluoroethoxy)Pyridine 2-(Trifluoromethoxy)Aniline 2-(Trifluoromethoxy)Benzaldehyde 2-(Trifluoromethoxy)Benzoic Acid 2-(Trifluoromethoxy)Benzonitrile 2-(Trifluoromethoxy)Phenol 2-(Trifluoromethoxy)Pyridine 2-(Trifluoromethyl)-1,1'-Biphenyl 2-(Trifluoromethyl)Aniline 2-(Trifluoromethyl)Benzaldehyde 2-(Trifluoromethyl)Benzamide 2-(Trifluoromethyl)Benzoic Acid 2-(Trifluoromethyl)Benzonitrile 2-(Trifluoromethyl)Phenol 2-(Trifluoromethyl)Pyrazine 2-(Trifluoromethyl)Pyridine 2-(Trifluoromethyl)Pyrimidine 2-(Trifluoromethyl)Quinazoline 2-(Trifluoromethyl)Thiazole 2-(Trifluoromethyl)Thiophene 2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene 2-Bromo-4-(Trifluoromethyl)Aniline 2-Bromo-6-(Trifluoromethyl)Aniline 2-Chloro-3-(Trifluoromethyl)Aniline 2-Chloro-4-(Trifluoromethyl)Pyrimidine 2-Chloro-6-(Trifluoromethyl)Aniline 2-Methoxy-3-(Trifluoromethyl)Pyridine 2-Methoxy-5-(Trifluoromethyl)Pyridine 2-Phenoxy-5-(Trifluoromethyl)Pyridine 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine 3-(Trifluoromethoxy)Aniline 3-(Trifluoromethoxy)Benzaldehyde 3-(Trifluoromethoxy)Benzoic Acid 3-(Trifluoromethoxy)Benzonitrile 3-(Trifluoromethoxy)Phenol 3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine 3-(Trifluoromethyl)Aniline 3-(Trifluoromethyl)Benzaldehyde 3-(Trifluoromethyl)Benzenesulfonyl Chloride 3-(Trifluoromethyl)Benzoic Acid 3-(Trifluoromethyl)Benzonitrile 3-(Trifluoromethyl)Phenol 3-(Trifluoromethyl)Pyridazine 3-(Trifluoromethyl)Pyridin-2-Ol 3-(Trifluoromethyl)Pyridine 3-Chloro-4-(Trifluoromethyl)Aniline 4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione 4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane 4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane 4-(Trifluoromethoxy)Aniline 4-(Trifluoromethyl)-2H-Chromen-2-One 4-(Trifluoromethyl)Phenol 4-(Trifluoromethyl)Pyridine 4-(Trifluoromethyl)Pyrimidin-2-Amine 4-(Trifluoromethyl)Pyrimidine 4-(Trifluoromethyl)Thiazole 4-Bromo-3-(Trifluoromethyl)Aniline 5-(Trifluoromethyl)Pyridin-2-Amine 5-(Trifluoromethyl)Pyridin-2-Ol 6-(Trifluoromethyl)-1H-Indazole 6-(Trifluoromethyl)-1H-Indole 6-(Trifluoromethyl)Pyridin-2-Amine 6-(Trifluoromethyl)Pyridin-3-Amine Methyl 2-(Trifluoromethyl)Benzoate Methyl 3-(Trifluoromethyl)Benzoate N-Phenyl-4-(Trifluoromethyl)Aniline Phenyl(3-(Trifluoromethyl)Phenyl)Methanone Phenyl(Trifluoromethyl)Sulfane

By Key Group+−

(R)-2,2,2-Trifluoro-1-Ethanamine (S)-2,2,2-Trifluoro-1-Ethanamine (Trifluoromethyl)Thio 1,1,1,3,3,3-Hexafluoropropan-2-Ol 2,2,2-Trifluoro Ethanamine 2,2,2-Trifluoro Ethanol 2,2,2-Trifluoroacetamido 2,2,2-Trifluoroethoxy 2,2,2-Trifluoroethyl 4,4,4-Trifluoro-1,3-Dione Bistrifluoromethyl Bromo-Trifluoromethyl-Pyrazole Bromo-Trifluoromethyl-Pyridine Bromo-Trifluoromethyl-Pyrimidine Bromo-Trifluoromethyl-Quinoline Bromobenzotrifluoride Chloro-Iodo-Trifluoromethyl-Pyridine Chloro-Trifluoromethyl-Pyridin-Amine Chloro-Trifluoromethyl-Pyridine Chloro-Trifluoromethyl-Pyrimidine Chloro-Trifluoromethyl-Quinoline Chlorobenzotrifluoride Fluoro-Trifluoromethyl-Pyridine Fluorobenzotrifluoride Hydroxy-Trifluoromethyl Iodo-Trifluoromethyl-Pyridine Iodobenzotrifluoride Methoxy-Trifluoromethyl-Benzene Methoxy-Trifluoromethyl-Pyridine Nitro-Trifluoromethyl-Benzene Nitro-Trifluoromethyl-Pyridin Trifluoro-Ethanone Trifluoroacetic Trifluoromethanamine Trifluoromethyl-Acetophenone Trifluoromethyl-Amine Trifluoromethyl-Benzene-Sulfonyl Chloride Trifluoromethyl-Benzimidazole Trifluoromethyl-Benzo Trifluoromethyl-Benzothiazole Trifluoromethyl-Benzothiophene Trifluoromethyl-Benzoxazole Trifluoromethyl-Benzyl Trifluoromethyl-Chroman Trifluoromethyl-Cinnamic-Acid Trifluoromethyl-Furan Trifluoromethyl-Hydroxy-Quinoline Trifluoromethyl-Imidazo Trifluoromethyl-Imidazole Trifluoromethyl-Imidazopyridine Trifluoromethyl-Indazole Trifluoromethyl-Indene Trifluoromethyl-Indole Trifluoromethyl-Indoline Trifluoromethyl-Isoquinoline Trifluoromethyl-Nicotinate Trifluoromethyl-Nicotinic Acid Trifluoromethyl-Oxazole Trifluoromethyl-Phenyl-Acetate Trifluoromethyl-Phenyl-Borate Trifluoromethyl-Phenyl-Boronic Acid Trifluoromethyl-Phenyl-Ethanamine Trifluoromethyl-Phenyl-Ethanol Trifluoromethyl-Phenyl-Ethylamine Trifluoromethyl-Phenyl-Hydrazine Trifluoromethyl-Phenyl-Hydrochloride Trifluoromethyl-Phenyl-Methanamine Trifluoromethyl-Phenyl-Methanol Trifluoromethyl-Phenyl-Morpholine Trifluoromethyl-Phenyl-One Trifluoromethyl-Phenyl-Phosphino Trifluoromethyl-Phenyl-Piperazin Trifluoromethyl-Phenyl-Piperidine Trifluoromethyl-Phenyl-Propanol Trifluoromethyl-Phenyl-Pyrazin Trifluoromethyl-Phenyl-Pyrazol Trifluoromethyl-Phenyl-Pyrimidin Trifluoromethyl-Phenyl-Pyrrolidine Trifluoromethyl-Phenyl-Thiazole Trifluoromethyl-Phenyl-Urea Trifluoromethyl-Picolinamide Trifluoromethyl-Piperazine Trifluoromethyl-Piperidine Trifluoromethyl-Pyrazine Trifluoromethyl-Pyrazol-Amide Trifluoromethyl-Pyrazole Trifluoromethyl-Pyrazolone Trifluoromethyl-Pyridazine Trifluoromethyl-Pyridin-Amine Trifluoromethyl-Pyridin-Methanol Trifluoromethyl-Pyridine-Ethylamine Trifluoromethyl-Pyridyl-Methanamine Trifluoromethyl-Pyrimidin-Amine Trifluoromethyl-Pyrimidin-Ol Trifluoromethyl-Pyrrolo Trifluoromethyl-Quinazoline Trifluoromethyl-Quinolin-Amine Trifluoromethyl-Quinoxaline Trifluoromethyl-Sulfonyl Trifluoromethyl-Tetrahydroisoquinoline Trifluoromethyl-Thiazol Trifluoromethyl-Thio Trifluoromethyl-Thiophene Trifluoromethylaniline Trifluoromethylphenol Trifluoromethylphenyl Trifluoromethylpyridine Trifluoromethylpyridine-Indenoxazole Trifluoromethylpyrimidine Trifluoromethylquinoline Trifluoromethylsulfonyl Trifluorotoluene-Dioxaborane

By Parent Nucleus+−

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