Inhibitors/Agonists Membrane Transporter/Ion Channel CRAC Channel

CRAC Channel

CRAC channels, or Calcium Release-Activated Calcium channels, are crucial components of cellular calcium signaling. Family members include ORAI and STIM proteins, which structurally consist of transmembrane proteins and endoplasmic reticulum calcium sensors. These channels are primarily located on the cell membrane and endoplasmic reticulum, regulating calcium balance inside and outside cells. They play a role in various biological processes and signaling pathways, such as cell proliferation, differentiation, and apoptosis. Gene-specific expression and functional mutations of CRAC channels are closely related to various diseases, including immunodeficiency, muscle disorders, and neurodegenerative diseases.