The PPAR (Peroxisome Proliferator-Activated Receptor) family comprises three subtypes: PPARα, PPARδ (or β), and PPARγ. They are members of the nuclear receptor superfamily and share common structural domains, including a DNA-binding domain and a ligand-binding domain. Primarily located in the cell nucleus, they play a crucial role in fatty acid metabolism, insulin sensitivity, and inflammatory responses. PPARs regulate the expression of target genes by binding to specific DNA sequences. The tissue-specific expression of PPAR subtypes in different organs is associated with the development of various diseases such as diabetes, obesity, and cardiovascular disorders. Genetic mutations or alterations in expression can impact their regulatory networks, thereby influencing the risk of related diseases.