Home Chemistry Organic Building Blocks Carboxylic Acids 2-Chloro-4-Fluorobenzoic Acid
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—COOH,—F).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Decarboxylation: Under certain conditions, benzoic acid can undergo decarboxylation, where it loses a carbon dioxide molecule from its carboxylic acid group. This reaction usually requires high temperatures and is often observed in the presence of strong acids or bases.
Metalation Reactions: Fluorobenzene can undergo metalation reactions, where a metal species (such as an organolithium or organomagnesium compound) replaces a hydrogen atom on the benzene ring. These metalated intermediates can then be used in various synthetic transformations.
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