Chemistry Heterocyclic Building Blocks Pyrazoles

Pyrazoles

Pyrazole is an organic compound that has a molecular formula of C3H3N2H. It is classified as a heterocycle, consisting of a five-membered ring comprising of three carbon atoms and two adjacent nitrogen atoms that are in the ortho-substitution position.

Pyrazole is an organic heterocyclic compound that contains a ring structure consisting of two nitrogen atoms and three carbon atoms in adjacent positions, and has the molecular formula C3H4N2.

A variety of pesticides such as fungicides, insecticides, and herbicides contain the pyrazole ring, which can be found in compounds like fenpyroximate, fipronil, tebufenpyrad, and tolfenpyrad.

Pyrazoles that have no substitution at the 1-position exhibit NH-acidity, allowing them to react with electrophiles. In terms of its basic nature, Pyrazole has a pKa value of 14.21, which is comparable to that of imidazole.

Pyrazole rings exhibit high resistance to the majority of oxidizing agents; however, they can be readily transformed into pyrazoline through hydrogenation using a reductive metal catalyst.

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(1-methyl-1H-pyrazol-3-yl)methanol (1-phenyl-1H-pyrazol-4-yl)boronic acid 1,3-dimethyl-1H-pyrazole 1,3-diphenyl-1H-pyrazole 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1,5-diphenyl-1H-pyrazole 1-(2-chlorophenyl)-1H-pyrazole 1-(3-chlorophenyl)-1H-pyrazole 1-(4-methoxybenzyl)-1H-pyrazole 1-(azetidin-3-yl)-1H-pyrazole 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole 1-benzyl-1H-pyrazolo[3,4-b]pyridine 1-benzyl-4-bromo-1H-pyrazole 1-benzyl-4-iodo-1H-pyrazole 1-cyclopentyl-1H-pyrazole 1-cyclopropyl-1H-pyrazole 1-methyl-1H-pyrazol-3-amine 1-methyl-3-phenyl-1H-pyrazole 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-methyl-5-phenyl-1H-pyrazole 1-phenyl-1H-pyrazol-3-amine 1-phenyl-1H-pyrazol-3-ol 1-phenyl-1H-pyrazol-5-amine 1-phenyl-1H-pyrazole-3-carboxylic acid 1-phenyl-1H-pyrazole-4-carbaldehyde 1-phenyl-1H-pyrazole-4-carbonitrile 1-phenyl-1H-pyrazole-4-carboxylic acid 1-phenyl-1H-pyrazole-5-carboxylic acid 1-phenyl-3-(trifluoromethyl)-1H-pyrazole 1-trityl-1H-pyrazole 1H-pyrazol-4-amine 1H-pyrazol-4-ol 1H-pyrazol-5-amine 1H-pyrazole-4-carbaldehyde 1H-pyrazole-4-carbonitrile 1H-pyrazole-4-carboxylic acid 1H-pyrazole-4-sulfonyl chloride 1H-pyrazole-5-carboxamide 1H-pyrazole-5-carboxylic acid 1H-pyrazolo[3,4-b]pyrazine 1H-pyrazolo[3,4-b]pyridin-5-amine 1H-pyrazolo[3,4-d]pyrimidin-4-amine 1H-pyrazolo[4,3-d]pyrimidine 2,3-dihydropyrazolo[5,1-b]oxazole 2,4-dihydro-3H-pyrazol-3-one 2,6-di(1H-pyrazol-1-yl)pyridine 2-(1H-pyrazol-1-yl)pyridine 2-(1H-pyrazol-1-yl)pyrimidine 2-(1H-pyrazol-3-yl)pyridine 2-phenyl-2,4-dihydro-3H-pyrazol-3-one 3-(tert-butyl)-1-phenyl-1H-pyrazole 3-bromo-1-methyl-1H-pyrazole 3-bromopyrazolo[1,5-a]pyridine 3-bromopyrazolo[1,5-a]pyrimidine 3-chloro-1-methyl-1H-pyrazole 3-cyclopropyl-1H-pyrazole 3-iodo-1-methyl-1H-pyrazole 3-iodo-1H-pyrazolo[3,4-b]pyridine 3-methyl-1-phenyl-1H-pyrazole 3-phenyl-1H-pyrazol-5-amine 4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine 4-(1H-pyrazol-1-yl)benzoic acid 4-(1H-pyrazol-1-yl)piperidine 4-bromo-1-methyl-1H-pyrazole 4-bromo-1-phenyl-1H-pyrazole 4-bromo-1H-pyrazolo[3,4-b]pyridine 4-bromopyrazolo[1,5-a]pyridine 4-chloro-1H-pyrazole 4-chloro-1H-pyrazolo[3,4-b]pyridine 4-chloro-1H-pyrazolo[3,4-d]pyrimidine 4-iodo-1H-pyrazole 4-methyl-1-phenyl-1H-pyrazole 4-methyl-1H-pyrazole 4-nitro-1H-pyrazole 4-phenyl-1H-pyrazole 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole 5-(difluoromethyl)-1H-pyrazole 5-bromo-1H-pyrazole 5-bromo-1H-pyrazolo[3,4-b]pyridine 5-bromo-1H-pyrazolo[3,4-c]pyridine 5-chloro-1H-pyrazole 5-chloro-1H-pyrazolo[3,4-b]pyridine 5-chloropyrazolo[1,5-a]pyrimidine 5-cyclopropyl-1H-pyrazole 5-iodo-1H-pyrazole 5-nitro-1H-pyrazole 5-nitro-1H-pyrazolo[3,4-b]pyridine 5-phenyl-1H-pyrazole-3-carboxylic acid 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine 6-bromopyrazolo[1,5-a]pyridine 6-bromopyrazolo[1,5-a]pyrimidine 6-chloro-1H-pyrazolo[3,4-d]pyrimidine 7-chloropyrazolo[1,5-a]pyrimidine ethyl 1-phenyl-1H-pyrazole-3-carboxylate ethyl 1-phenyl-1H-pyrazole-4-carboxylate ethyl 1H-pyrazole-4-carboxylate ethyl pyrazolo[1,5-a]pyridine-3-carboxylate ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate methyl 1H-pyrazole-4-carboxylate methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate methyl pyrazolo[1,5-a]pyridine-3-carboxylate pyrazolo[1,5-a]pyrazine pyrazolo[1,5-a]pyridine-2-carboxylic acid pyrazolo[1,5-a]pyridine-3-carboxylic acid pyrazolo[1,5-a]pyrimidine-3-carboxylic acid tert-butyl 1H-pyrazolo[3,4-b]pyridine-1-carboxylate tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

By Key Group+−

amino-pyrazole-carboxylate amino-pyrazolopyridine aminopyrazolo benzylpyrazol-amide bipyrazole bromo-methyl-pyrazole bromo-pyrazol-amide bromo-pyrazole-carboxylate bromo-pyrazolopyridine bromo-pyrazolopyrimidine bromo-trifluoromethyl-pyrazole bromopyrazolo chloro-methyl-pyrazole chloro-pyrazolamide chloro-pyrazole chloro-pyrazole-carboxylate chloro-pyrazolopyridine chloro-pyrazolopyrimidine chloropyrazolo dichloropyrazolo difluoromethyl-pyrazole difluoromethyl-pyrazole-carboxylate dihydropyrazolo dimethyl-pyrazol-amide dimethyl-pyrazole-carboxylate dimethyl-pyrazole-carboxylic acid dimethylpyrazole dimethylpyrazolo dioxaborolan-pyrazole ethyl-pyrazol-amide ethylpyrazole fluoropyrazolo hydroxy-pyrazole hydroxy-pyrazolopyrimidine hydroxypyrazolo iodo-methyl-pyrazole iodo-pyrazole-carboxylate iodopyrazolo isopropyl-pyrazol-amide methoxy-pyrazolo-pyridine methoxypyrazolo methy-pyrazolooxazine methyl-hydrox-ypyrazole methyl-nitro-pyrazole methyl-pyrazol-one methyl-pyrazole-carboxylic acid methyl-pyrazole-carboxylic-acid methyl-pyrazolone methyl-pyrazolopyridine methylpyrazole methylpyrazolo nitro-pyrazole-carboxylate phenyl-pyrazol-amide phenyl-pyrazole-carboxylate phenyl-pyrazolidine phenylpyrazole pyrazo-morpholine pyrazol-amine pyrazol-boronic acid pyrazol-methanol pyrazol-one pyrazol-piperazine pyrazol-pyridine pyrazole-carbonitrile pyrazole-carboxylate pyrazole-carboxylic acid pyrazole-ethanol pyrazole-hydrochloride pyrazole-methamine pyrazole-phenyl-boronic-acid pyrazole-piperidine pyrazolo-pyrimidine pyrazolooxazine pyrazolopyrazine pyrazolopyridin-ol pyrazolopyridin-one pyrazolopyridine pyrazolopyridine-carbonitrile pyrazolopyridine-carboxylate pyrazolopyridine-carboxylic acid pyrazolopyridine-carboxylic-acid pyrazolopyridine-methanol pyrazolopyrimid-one pyrazolopyrimidine pyrazolotriazine pyridine-pyrazole pyrimidine-pyrazole pyrrolopyrazole tetrahydropyran-pyrazole tetrahydropyranopyrazole tetrahydropyrazolo trifluoromethyl-phenyl-pyrazol trifluoromethyl-pyrazol-amide trifluoromethyl-pyrazole trifluoromethyl-pyrazolone

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Furans Guanidines Imidazoles Indazoles Indoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxetanes Piperazines Piperidines Pyrazines Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinolines Tetrahydrofurans Tetrahydropyrans Thiophenes

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Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazones Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Sulfonyl Chlorides Trifluoromethyls Ureas

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    Taladegib

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    Taladegib

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    (S)-Benzyl (1-(4-amino-5-carbamoyl-1H-pyrazol-1-yl)propan-2-yl)carbamate

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    (S)-Benzyl (1-(4-amino-5-carbamoyl-1H-pyrazol-1-yl)propan-2-yl)carbamate

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    6-Benzyl-1,2,4,5,6,7-hexahydro-3H-pyrazolo[3,4-c]pyridin-3-one hydrochloride

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    6-Benzyl-1,2,4,5,6,7-hexahydro-3H-pyrazolo[3,4-c]pyridin-3-one hydrochloride

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    Benzyl (S)-(1-(4-nitro-1H-pyrazol-1-yl)propan-2-yl)carbamate

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    Benzyl (S)-(1-(4-nitro-1H-pyrazol-1-yl)propan-2-yl)carbamate

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    4-(3,5-Di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

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    4-(3,5-Di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

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    4-(Cyclohex-1-en-1-yl)-3-phenyl-1H-pyrazol-5-amine

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    4-(Cyclohex-1-en-1-yl)-3-phenyl-1H-pyrazol-5-amine

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    4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-b]pyridine hydrochloride

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    4,5,6,7-Tetrahydro-1H-pyrazolo[4,3-b]pyridine hydrochloride

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    (E)-2-(3,5-Dimethyl-4-(phenyldiazenyl)-1H-pyrazol-1-yl)acetic acid

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    (E)-2-(3,5-Dimethyl-4-(phenyldiazenyl)-1H-pyrazol-1-yl)acetic acid

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    2,4,5,6,7,8-Hexahydrocyclohepta[c]pyrazole hydrochloride

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    2,4,5,6,7,8-Hexahydrocyclohepta[c]pyrazole hydrochloride

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    2-Bromopyrazolo[1,5-a]pyrimidin-7(1H)-one

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    2-Bromopyrazolo[1,5-a]pyrimidin-7(1H)-one

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    2-([6-(3,5-Dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazin-3-yl]amino)-2-(hydroxymethyl)propane-1,3-diol

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    A7742861199215-75-295%

    2-([6-(3,5-Dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazin-3-yl]amino)-2-(hydroxymethyl)propane-1,3-diol

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    3-(Oxolan-3-yl)-1H-pyrazol-5-amine

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    3-(Oxolan-3-yl)-1H-pyrazol-5-amine

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    6-Chloro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

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    6-Chloro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

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    1H-Pyrazolo[3,4-b]pyridin-5-ol

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    1H-Pyrazolo[3,4-b]pyridin-5-ol

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    5,7-Dichloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-c]pyridine

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    5,7-Dichloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-c]pyridine

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    1-[2-(4-Nitro-1H-pyrazol-1-yl)ethyl]piperazine

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    A9437641248142-10-090%

    1-[2-(4-Nitro-1H-pyrazol-1-yl)ethyl]piperazine

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    (1-Methyl-1H-pyrazol-5-yl)methanamine

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    (1-Methyl-1H-pyrazol-5-yl)methanamine

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    1-Ethyl-1H-pyrazol-4-amine

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    1-Ethyl-1H-pyrazol-4-amine

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    Ethyl 5-Propylpyrazole-3-carboxylate

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    Ethyl 5-Propylpyrazole-3-carboxylate

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    4-Nitro-1H-pyrazole-1-acetonitrile

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    4-Nitro-1H-pyrazole-1-acetonitrile

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