Inhibitors/Agonists Apoptosis c-RET

c-RET

c-RET is a member of the tyrosine kinase receptor family, primarily composed of an extracellular domain, a transmembrane region, and an intracellular tyrosine kinase activity domain. This receptor primarily functions in the development of neural crest cells and the adrenal gland, being localized in various cell types, particularly in the nervous and urogenital systems. c-RET regulates cell proliferation, migration, and differentiation by activating signaling pathways such as MAPK and PI3K-Akt. Its gene expression is tissue-specific and crucial for the development of neuroglial cells. Mutations in the c-RET gene are associated with various diseases, including multiple endocrine neoplasia type 2 (MEN2) and familial medullary thyroid carcinoma.